The Standard Concentration of Morphine as a Positive Control for Intradermal Skin Test

Intradermal Test Clinical Trial

Official title:

The Standard Concentration of Morphine as a Positive Control for Intradermal Skin Test

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00853476
• Other study ID #: Chula-ARC 001/09
• Status: Completed
• Phase: N/A
• First received: February 27, 2009
• Last updated: February 16, 2011
• Start date: March 2009
• Est. completion date: October 2009

Study information

• Verified date: February 2011
• Source: Chulalongkorn University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Ethical Committee
• Study type: Observational

Clinical Trial Summary

This study aims to compare skin reactivity results between morphine and histamine as a positive control agents in intradermal skin test.

Description:

Histamine hydrochloride and different concentrations of morphine sulfate will be intradermally injected and wheal diameter size will be comparatively measured between 15-30 minutes' time points after the test.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: October 2009
• Est. primary completion date: October 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• age 18-60 years old

Exclusion Criteria:

• immunodeficiency state

• cancer

• severe skin diseases

• severe medical illnesses

• malnutrition

• uncontrolled asthma

• pregnancy

• received oral or systemic corticosteroid within 1 month before this study

• receiving immunosuppressive agents

• taken antihistamine within 3 days before this study

• taking beta-blocker

• previous history of immunotherapy

• have hypersensitivity reaction to morphine/opiates

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Intradermal Test

Locations

Country	Name	City	State
Thailand	Faculty of Medicine, Chulalongkorn University	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Chulalongkorn University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Wheal diameter from morphine skin test at different concentrations compared to standard histamine between 15-30 minutes after skin test		30 minutes	No
Secondary	Side effects		24 hours	Yes

External Links

•   http://www.ncbi.nlm.nih.gov/pubmed/21314010