Intracranial Arterial Aneurysm Clinical Trial
Official title:
Hemodynamic Analysis Of Intracranial Artery And Associated Lesions Using 2-D/3D Phase Contrast MR Angiography Focused On Wall Shear Stress Measurement
Using phase contrast MR Angiography with NOVA® Software, this study intends to identify,evaluate and map intracranial aneurysm development as well as develope a predicator for future morphological changes of aneurysms and possible risk of future rupture.
Hemodynamic stress toward the wall of intracranial artery with associated genuine defects of
wall remodeling capacity is one of many hypotheses of subarachnoid aneurysm development. In
addition, hemodynamic stress toward an aneurysm wall may play a very significant role for
the rupture of an aneurysm creating acute Subarachnoid hemorrhage. We think the Wall Shear
Stress (WSS) measurement toward an intracranial arterial wall and intracranial aneurysmal
wall may provide valuable information for understanding of intracranial aneurysm development
as well as predicting future morphological changes of aneurysm and possibly risk of future
rupture. This study is significant especially in the management of unruptured subarachnoid
arterial aneurysm patients and identifying patients who have higher rupture risks for active
treatments such as surgical clipping or coiling to prevent unnecessary but potentially risky
procedures.
Gadolinium MR Angiography with NOVA® Software will be used to measure the arterial wall
shear stress (WSS) for patients with an intracranial arterial aneurysm. The aneurysm will be
identified, blood flow, velocity, volume, vascular diameter and the direction of blood
measurements will be taken using NOVA® Software at each point of interest. A WSS map of
target intracranial artery and/or aneurysm sac will be created and matched with
morphological features providing a clue to understand the the relationships between
hemodynamic parameters, especially WSS and morphological changes.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic