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NCT06426524 Clinical Trial

Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study

Intrabony Periodontal Defect Clinical Trial

Official title:
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06426524
Other study ID # SVSInstituteDS1
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date May 19, 2023
Est. completion date May 2024

Study information
Verified date May 2024
Source SVS Institute of Dental Sciences
Contact Dr R Viswa Chandra, MDS;DNB;PhD
Phone 8179367147
Email viswachandra@hotmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.

Description:

In test group, after reflection of flap and degranulation, IGF-1 gel with hydroxyapatite will be placed in the defect and sutures will be placed. In control group, after reflection of flap and degranulation, hydroxyapatite will be placed in the defect and sutures will be placed.

Recruitment information / eligibility
Status Recruiting
Enrollment 24
Est. completion date May 2024
Est. primary completion date May 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Systemically healthy male and female patients of age >18 years Intrabony defects - two wall or three wall defects Probing pocket depths (PPD) of >5mm. Exclusion Criteria: Medically compromised patients Pregnant women Heavy smokers Patients who underwent radiotherapy or chemotherapy are excluded

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• IGF-1 Gel
After degranulation of the defect, IGF-1 gel mixed with Hydroxyapatite graft will be placed in the defect.
• Hydroxyapatite
After degranulation of the defect, Hydroxyapatite graft will be placed in the defect.

Locations
Country Name City State
India SVS Institute of Dental Sciences, Mahabubnagar Hyderabad Telangana

Sponsors (1)
Lead Sponsor Collaborator
Dr R Viswa Chandra

Country where clinical trial is conducted

India, 

Outcome
Type Measure Description Time frame Safety issue
Primary Bone Regeneration Radiovisiography (RVG) will be used to assess bone regeneration achieved post operatively after 3 months and 6 months. 3 months and 6 months
Primary clinical attachment level Assessment of clinical attachment level using UNC-15 probe at baseline and post operatively at 3 and 6 months. 3 months and 6 months
Primary Probig depth Assessment of probing depth using UNC-15 probe at baseline and postoperatively at 3 and 6 months. 3 months and 6 months
Secondary Plaque Index Assessment of plaque (PI) - according to Turesky modification of Quigley and Hein Plaque Index, 1970. 3 months and 6 months
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