Intrabony Periodontal Defect Clinical Trial
Official title:
Clinical and Radiographic Evaluation of Modified Minimally Invasive Surgical Technique and Platelet Rich Fibrin With or Without Vitamin Pool A and C for Management of Periodontal Intrabony Defects: A Randomized Controlled Clinical Trial
This study aims to assess clinical and radiographic outcomes after the use of vitamins A and C with PRF versus PRF alone in the treatment of periodontal intrabony defect.
Status | Not yet recruiting |
Enrollment | 28 |
Est. completion date | October 30, 2023 |
Est. primary completion date | November 1, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Patient-related criteria: - Patient consulting in the outpatient clinic with periodontitis stage III - Able to tolerate surgical periodontal procedures. - Patient ready to perform oral hygiene instructions. - Compliance with the maintenance program. - Provide informed consent. - Accepts the 6 months follow-up period. Teeth related criteria: - Mature permanent tooth. - Tooth with two or three-walled intra-bony defect, with CAL = 5mm and intra osseous defect = 3mm. Exclusion Criteria: - Patient-related criteria: - Medically compromised patients. - Pregnant or nursing women. - Uncooperative patients. - Smokers. Teeth related criteria: - Teeth with one wall intra-bony defect. - Teeth with supra-bony defects. - Teeth with grade III mobility. |
Country | Name | City | State |
---|---|---|---|
Egypt | Cairo University | Cairo |
Lead Sponsor | Collaborator |
---|---|
Cairo University |
Egypt,
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e37-44. Epub 2006 Jan 19. — View Citation
Elbehwashy MT, Hosny MM, Elfana A, Nawar A, Fawzy El-Sayed K. Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of stage-III periodontitis patients: a randomized controlled clinical trial. Clin Oral Investig. 2021 Nov;25(11):6309-6319. doi: 10.1007/s00784-021-03929-1. Epub 2021 Apr 12. — View Citation
Fawzy El-Sayed KM, Hein D, Dörfer CE. Retinol/inflammation affect stemness and differentiation potential of gingival stem/progenitor cells via Wnt/ß-catenin. J Periodontal Res. 2019 Aug;54(4):413-423. doi: 10.1111/jre.12643. Epub 2019 Mar 4. — View Citation
Heitz-Mayfield LJ, Lang NP. Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000. 2013 Jun;62(1):218-31. doi: 10.1111/prd.12008. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Radiographic linear defect depth (mm) | Digital Radiographs using ImageJ software, Measured as the depth of intra-osseous defect from the alveolar crest to the defect. | 9 months | |
Secondary | Probing depth (mm) | Measured from the gingival margin to the bottom of the gingival sulcus | 9 months | |
Secondary | Clinical Attachment Level (mm) | Measured from the CEJ to the bottom of the gingival sulcus | 9 months | |
Secondary | Gingival Recession Depth (mm) | Measured from the CEJ to the most apical extension of the gingival margin | 9 months |
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