Intraabdominal Infections Clinical Trial
Official title:
Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis
An observational, prospective study whose main objective is to measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.
Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis
Research Type:
Prospective, observational study.
Duration:
October 2016 - October 2017
Associated Medical Centers:
La Paz University Hospital (Madrid), La Princesa Hospital (Madrid), Hospital del Mar
(Barcelona), Hospital Clínico de Valladolid and Hospital Clínico de Valencia.
Main Goal:
To measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality
in patients with intra-abdominal sepsis after damage control surgery.
Secondary Goals:
Make a comparison with other biomarkers (procalcitonin, lactic acid, CRP) and clinical
severity scales used in standard critical practice (SAPSII, SOFA).
To establish a correlation between the levels of Pro-Adrenomedullin, the time of stay in
critical care units, days of mechanical ventilation and mortality.
Variables:
A. Demographics
B. Date of admission to hospital and date of admission to critical care unit unit
C. Clinical data:
- Associated diseases
- SAPS II
- SOFA
D. Intra-abdominal infection episode data
- Systemic response: sepsis / septic shock
- Isolated microorganisms in blood cultures and intra-abdominal fluid
- Complications related to the infectious process (ARDS, need for mechanical ventilation,
vasopressors, disseminated intravascular coagulation, acute renal failure, renal
replacement techniques)
E. Follow-up
- Critical unit registration date
- Date of discharge from hospital
- Critical unit mortality, in-hospital mortality and 30 days mortality (assessed by
telephone contact if the patient had been discharged).
F. Pro-adrenomedullin levels at admission, 24 and 72 hours. As well as procalcitonin (PCT),
lactic acid and polymerase Chain Reaction (PCR) levels.
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