Internal Medicine Clinical Trial
Official title:
Polypharmacy and Associated Risk Factors and Clinical Outcomes for Internal Medicine Patients Discharged From Hospital
Verified date | January 2024 |
Source | University of Iceland |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue. One of the major contributing factors is polypharmacy, the usage of multiple medicines at the same time. People are getting older and living longer with chronic diseases; they need more medications, which frequently leads to polypharmacy. Subsequently, they are at more risk of medication-related harm. The planned project is an epidemiological study on polypharmacy, medication appropriateness, risk factors, and clinical outcomes post-discharge from a hospital for internal medicine patients. The study group hypothesise that pre- and post-admission polypharmacy and potentially inappropriate prescribing is common, especially among older patients, patients with a high comorbidity and frailty burden. Our hypothesis is additionally that preadmission polypharmacy and potentially inappropriate prescribing is associated with higher short- and long-term mortality, a longer primary hospitalization length of stay, and a higher risk of readmission.
Status | Active, not recruiting |
Enrollment | 85942 |
Est. completion date | May 1, 2024 |
Est. primary completion date | April 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Population-based cohort study that included all patients =18 years hospitalized in internal medicine ward at Landspitali - The National University Hospital of Iceland during the study period 1st January 2010 and 31st December 2020 Exclusion Criteria: - Under 18 years of age |
Country | Name | City | State |
---|---|---|---|
Iceland | Faculty of Pharmaceutical Sciences | Reykjavik |
Lead Sponsor | Collaborator |
---|---|
University of Iceland |
Iceland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of polypharmacy | Polypharmacy measured by by the number of different ATC classes of medications filled in the year preceding and year following surgery. Polypharmacy further quantified into categories of non-polypharmacy (<5), polypharmacy (5-9) and hyper-polypharmacy (=10). | Two years, one year pre-admission and one year post-admisson, 2010-2020 | |
Secondary | Incidence of polypharmacy | Polypharmacy measured by by the number of different ATC classes of medications filled in the year preceding and year following surgery. Polypharmacy further quantified into categories of non-polypharmacy (<5), polypharmacy (5-9) and hyper-polypharmacy (=10). | Two years, one year pre-admission and one year post-admisson, 2010-2020 | |
Secondary | Potentially inappropriate prescribing by Beers criteria 2019 | The association of potentially inappropriate prescribing by applying Beers criteria 2019 with polypharmacy (summary score, yes/no) | 2010-2020 | |
Secondary | Anticholinergic burden by applying the Anticholinergic burden scale | The association of anticholinergic burden by applying the Anticholinergic burden scale with polypharmacy ((summary score, yes/no) | 2010-2020 | |
Secondary | Demographics | Gender (male, female),age (years), comorbidity based on the International Statistical Classification of Diseases, and Related Health Problems, ninth or tenth revision, ICD9/10 classification system | 2010-2020 | |
Secondary | Comorbidity burden | The association of comorbidity burden will be described by calculating the Charlson Comorbidity Index and Elixhauser comorbidity index (summary score) with polypharmacy ((summary score, yes/no) | 2010-2020 | |
Secondary | Drug classes | Drug classes based on ATC-codes on filled medications from the Prescription Medicines Registry and association with polypharmacy | 2010-2020 | |
Secondary | Clinical outcomes | Mortality (short-and long-term mortality) Length of hospital stay (number of days, = ten days) Readmission (number of days until readmission, readmission <30 days) | 2010-2020 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05546034 -
Nutrition Screening - Route to a More Practical Method
|
||
Completed |
NCT03188211 -
E-learning to Improve Oral Anticoagulant Use in Hospitalized Older People With AF
|
N/A | |
Completed |
NCT01418846 -
Determination of Voriconazole Levels in Saliva - Validation in Specific Subsets of Patients
|
N/A | |
Completed |
NCT04797130 -
The Effect of Hospital Fit 2.0 on Patients Physical Activity
|
N/A | |
Completed |
NCT04139265 -
Transferrin Saturation Coefficient and Ferritinemia in Diagnosis of Iron Deficiency
|