Physical Training Per se — TPS  

Insulin Sensitivity Clinical Trial

Official title: Physical Activity is Healthy - Effect of Weight Loss or Physical Training Per se?

Status Completed

Clinical Trial Summary

The investigators aimed to evaluate the health benefits of physical training per se, weight loss per se and exercise-induced weight loss in young, overweight men. The investigators hypothesized that physical training would have independent effects on various health parameters (insulin sensitivity, fasting glucose and insulin, total and abdominal fat mass, waist circumference, blood pressure and key muscle proteins), and that a concomitant weight loss from physical activity would increase the effect.

Clinical Trial Description

At baseline, during the intervention and in the week following the intervention participants underwent a panel of tests:

• Cardio respiratory fitness

• blood pressure

• anthropometric measures

At baseline and after the intervention a hyperinsulinemic, euglycemic clamp were performed to asses insulin sensitivity.

Tissue and blood samples were also collected for further analysis:

• Total-protein analysis of selected proteins

• Fasting plasma glucose, insulin and free fatty acids ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Insulin Sensitivity

• NCT number: NCT01090869
• Study type: Interventional
• Source: University of Copenhagen
• Status: Completed
• Phase: N/A
• Start date: March 2007
• Completion date: June 2009