Magnesium Nutrition and Sleep Behavior in Older Adults

Insomnia Clinical Trial

Official title: Magnesium Nutrition and Sleep Behavior in Older Adults

Status Completed

Clinical Trial Summary

Insomnia is not a natural part of aging but is higher in older adults because of a variety of factors common in later life. One of these factors may be a deficient magnesium status. This study will look at whether or not magnesium supplementation will improve sleep.

Clinical Trial Description

Insomnia affects approximately one-third of older Americans. More than half of all people aged 65 and older experience sleep problems. The prevalence of insomnia and other sleep disorders is not a natural part of aging but is high in older adults because of a variety of factors common in late life. One of those factors may be a deficient magnesium status. There is a close association between sleep architecture, especially slow wave sleep, and activity in the glutamatergic and gamma-aminobutyric acid (GABA) system. Because magnesium is a natural N-methyl-D-aspartate (NMDA)antagonist and GABA agonist, magnesium apparently plays a key role in the regulation of sleep. Such a role is supported by supplementation, correlation, and animal studies showing that magnesium intake or status affects sleep organization. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Insomnia
• Malnutrition
• Nutritional Deficiency

• NCT number: NCT00833092
• Study type: Interventional
• Source: USDA Grand Forks Human Nutrition Research Center
• Status: Completed
• Phase: N/A
• Start date: January 2008
• Completion date: December 2008