Inhalation Injury Clinical Trial
Official title:
Burn Multicenter Proposal: Development of an Inhalation Injury Scoring System to Predict Severity of Inhalation Injury
Verified date | July 2021 |
Source | American Burn Association |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy
Status | Completed |
Enrollment | 108 |
Est. completion date | September 29, 2019 |
Est. primary completion date | September 29, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Injury consistent with inhalation of smoke or products of combustion - Requires intubation within 24 hours of injury - Meets one of the following 4 criteria 1. history of closed space injury 2. carbonaceous sputum 3. elevated carboxyhemoglobin 4. dx of inhalation injury is considered likely by investigator Exclusion Criteria: - = 17 years of age - Prisoner |
Country | Name | City | State |
---|---|---|---|
United States | The Metro Health System | Cleveland | Ohio |
United States | University of Texas Southwestern Medical Center | Dallas | Texas |
United States | Indiana University | Indianapolis | Indiana |
United States | Arkensas Children's Hopital | Little Rock | Arkansas |
United States | Loyola University | Maywood | Illinois |
United States | University of Tennessee Health Science Center | Memphis | Tennessee |
United States | The Arizona Burn Center, Maricopa Integrated Health Systems | Phoenix | Arizona |
United States | University of California Davis Medical Center | Sacramento | California |
United States | Wake Forest University Health Sciences | Winston-Salem | North Carolina |
Lead Sponsor | Collaborator |
---|---|
American Burn Association | U.S. Army Medical Research and Development Command |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Development of a diagnostic model to predict the severity of inhalation injury | The development of a diagnostic model to predict the severity of inhalation injury based on demographics, characteristics of injury, bronchoscopy, CT scan, and inflammatory markers. | within 48 hours of admission | |
Secondary | Impact of inhalation injury | Assessment of the impact of inhalation injury on the incidence of pneumonia, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI). | at discharge |
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