Infratentorial Neoplasms Clinical Trial
Official title:
Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery
The sitting or prone positions are used for posterior fossa surgery. Although the sitting
position may cause hemodynamic instability, venous air embolism, it also provides optimum
access to midline lesions, decreases intracranial pressure. The sitting position has not
been only used in neurosurgery, it has been also used in the shoulder surgery. The sitting
position related hypotension may reduce the cerebral perfusion pressure, therefore may cause
cerebral ischemia. The sitting position related cerebral ischemia has been shown in the
shoulder surgery. The non invasive cerebral oxymetry (INVOS-Covidien) has been used to
measure cerebral oxygen saturation. Some studies has been done to investigate whether the
sitting position cause cerebral desaturation or not in the shoulder surgery by non invasive
cerebral oxymetry. The study results are controversial.
It has been investigated that the effect of the prone position on the cerebral oxygenation
in the spine surgery and the investigators found that the prone position may increase
cerebral oxygenation.
However, all studies have been done in patients without intracranial pathology. We speculate
that due to the sitting position reduces the intracranial pressure, it may improve the
cerebral oxygenation in the patients have intracranial pathology. Therefore we will compare
the sitting and the prone positions effects on the cerebral oxygenation in patients
undergoing posterior fossa tumour surgery by non invasive cerebral oxymetry.
Method: 62 patients have posterior fossa tumour will include the study. Patients will divide
to 2 groups according to the surgical position, the prone (n=31) or the sitting (n=31).
Patients heart rate, mean blood pressure (MAP), cerebral oxygen saturation (SctO2),
peripheral oxygen saturation (SpO2), BIS values will record before the induction of
anesthesia. Five minutes after the standard anesthesia induction all values will record and
it will accept as a baseline. After that all these parameters will record in each 3 minutes
until the beginning of surgery. Mean while, more than 5 % reduction in SctO2 and more than
20 % reduction in SctO2 and/or MAP will record. As well as, if the SctO2 reduces than 55 and
60 %, it will record.
Status | Not yet recruiting |
Enrollment | 62 |
Est. completion date | October 2018 |
Est. primary completion date | October 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of infratentoril neoplasms Exclusion Criteria: Stroke - Diabetes mellitus - Chronic obstructive pulmonary disease - Anemia |
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
Turkey | Ozlem Korkmaz Dilmen | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Istanbul University |
Turkey,
Dilmen OK, Akcil EF, Tureci E, Tunali Y, Bahar M, Tanriverdi T, Aydin S, Yentur E. Neurosurgery in the sitting position: retrospective analysis of 692 adult and pediatric cases. Turk Neurosurg. 2011;21(4):634-40. doi: 10.5137/1019-5149.JTN .4974-11.0. — View Citation
Murphy GS, Szokol JW, Marymont JH, Greenberg SB, Avram MJ, Vender JS, Vaughn J, Nisman M. Cerebral oxygen desaturation events assessed by near-infrared spectroscopy during shoulder arthroscopy in the beach chair and lateral decubitus positions. Anesth Analg. 2010 Aug;111(2):496-505. doi: 10.1213/ANE.0b013e3181e33bd9. Epub 2010 May 27. — View Citation
Pohl A, Cullen DJ. Cerebral ischemia during shoulder surgery in the upright position: a case series. J Clin Anesth. 2005 Sep;17(6):463-9. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cerebral oxygen saturation | After anesthesia induction cerebral oxygen saturation will record in each 3 minutes until the beginning of surgery | Change from baseline cerebral oxygen saturation up to skin incision | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT02300766 -
Cerebellar Mutism Syndrome Study
|
||
Not yet recruiting |
NCT06036732 -
A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score
|
||
Completed |
NCT05192733 -
PRICE Survey Of Extubation Following Infratentorial Craniotomy
|
||
Completed |
NCT04232059 -
The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
|
N/A |