Effects of Resistance Exercise on Metabolic Responses

Inflammatory Response Clinical Trial

Official title:

Effects of Volume-matched Resistance Exercise With Different Loads on Metabolic Responses

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05051306
• Other study ID #: 202011HM005
• Status: Completed
• Phase: N/A
• Start date: February 18, 2021
• Est. completion date: December 31, 2021

Study information

• Verified date: March 2022
• Source: National Taiwan Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: December 31, 2021
• Est. primary completion date: March 7, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• Age: 20-30

• Healthy male

• Without experience of resistance training

Exclusion Criteria:

• No acute or chronic musculoskeletal symptoms

• Smoking

• Alcohol or drug abuse

• Fail to conduct resistance exercise

Related Conditions & MeSH terms

• Inflammatory Response

Intervention

Other:
• High-load resistance exercise
Subjects in high-load trial performed 4 sets per exercise, 8 repetitions with load of 85%-8RM with 90 sec of rest between sets.
• Low-load resistance exercise
Subjects in low-load trial performed 4 sets per exercise, 15 repetitions with load of 45%-8RM with 90 sec of rest between sets.

Locations

Country	Name	City	State
Taiwan	National Taiwan Normal University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan Normal University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in glucose	glucose in mg/dL	4-hour during each study intervention
Primary	Changes in insulin	insulin in mU/L	4-hour during each study intervention
Primary	Changes in TG	TG mg/dL	4-hour during each study intervention
Primary	Changes in uric acid	uric acid mg/dL.	4-hour during each study intervention
Secondary	Changes in biomarkers of inflammation	Biomarkers of inflammation will be measured such as IL-10 in pg/mL and IL-6 in pg/mL.	4-hour during each study intervention
Secondary	Changes in cortisol	cortisol in ng/mL	4-hour during each study intervention
Secondary	Changes in lactate	lactate in mmol/L	4-hour during each study intervention
Secondary	Changes in complete blood count	blood cell count in count per µL	4-hour during each study intervention
Secondary	Borgs Ratings of Perceived Exertion (RPE)	Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).	1-hour during each exercise intervention
Secondary	Changes in ET-1	ET-1 in pg/mL	4-hour during each study intervention
Secondary	Changes in NO	NO in µmol/L	4-hour during each study intervention
Secondary	Changes in biomarkers of muscle damage	Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.	4-hour during each study intervention
Secondary	Heart rate (HR)	HR will be measured during each study intervention.	6-hour during each study intervention
Secondary	Visual Analogue Scale (VAS) of appetite	Hunger, fullness, desire to eat, and prospective food consumption will be measured via VAS ratings, based on a 100 mm long scale (0 being "not at all", 100 being "extremely").	6-hour during each study intervention
Secondary	Changes in biomarkers of appetite	Biomarkers of appetite will be measured such as ghrelin in pg/mL and PYY in pg/mL.	4-hour during each study intervention