Inflammatory Response Clinical Trial
Official title:
Dairy Consumption During a High-intensity, High-volume Training Week in Young Athletes
Verified date | May 2022 |
Source | Brock University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Our proposed study is a 5-d double-blind randomised cross-over trial, seeking to simulate a training identification camp in competitive adolescent soccer players The purpose of the proposed study is to investigate whether increased protein consumption by Greek yogurt, compared to an isoenergetic carbohydrate (CHO) control supplement, consumed immediately following exercise training, prior to sleep and between breakfast and lunch, for a week during an intense training period (high volume, high intensity) will: - Attenuate the pro-inflammatory response (cytokines, acute phase proteins) - Reduced the severity of muscle damage and impairment (creatine kinase) - Maintain performance Secondary outcome measures: - Increase bone turnover (in favour of formation)
Status | Completed |
Enrollment | 30 |
Est. completion date | November 23, 2019 |
Est. primary completion date | November 23, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 11 Years to 16 Years |
Eligibility | Inclusion Criteria: - Participant are female within the desired age ranges (11-16y) - Participants are competitive soccer players - Previous participation in high-performance training environment (periodization) Exclusion Criteria: - Participant is not female or falls outside of the desired age ranges (11-16y) - Chronic/frequent use of medications that could affect inflammatory function - NSAIDS or Corticosteroids. - Musculoskeletal injury - resulting in the inability to train and/or perform the baseline/post testing. |
Country | Name | City | State |
---|---|---|---|
Canada | Elite soccer Development | Welland | Ontario |
Lead Sponsor | Collaborator |
---|---|
Brock University |
Canada,
Klentrou P, McKee K, McKinlay BJ, Kurgan N, Roy BD, Falk B. Circulating Levels of Bone Markers after Short-Term Intense Training with Increased Dairy Consumption in Adolescent Female Athletes. Children (Basel). 2021 Oct 25;8(11). pii: 961. doi: 10.3390/ch — View Citation
McKinlay BJ, Wallace PJ, Olansky S, Woods S, Kurgan N, Roy BD, Josse AR, Falk B, Klentrou P. Intensified training in adolescent female athletes: a crossover study of Greek yogurt effects on indices of recovery. J Int Soc Sports Nutr. 2022 Mar 22;19(1):17- — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Aerobic Capacity - Beep Test | Aerobic capacity using the - Beep test; units - distance (m) | 8 weeks | |
Other | Maximal sprint ability | Maximal sprint ability using a 20 m sprint test; units - time (s) | 8 weeks | |
Other | Explosive leg power - Vertical jump performance | Explosive leg power using the counter-movement jump; units - height (cm) | 8 weeks | |
Other | Agility and Quickness | Agility using the 5-10-5 pro-agility test; units - time (s) | 8 weeks | |
Primary | Body mass (kg) | Anthropometric measures | 8 weeks | |
Primary | Height (cm) | Anthropometric measures | 8 weeks | |
Primary | Seated height (cm) | Used to calculate maturity offset in years from peak height velocity | 8 weeks | |
Primary | Body fat (%) | Body composition | 8 weeks | |
Primary | Rate of perceived exertion | 1-10 scale of perceived exertion | 8 weeks | |
Primary | Serum concentrations of BAP (ng/ml) | Bone formation marker | 8 weeks | |
Primary | Serum concentrations of PINP (ng/ml) | Bone formation marker | 8 weeks | |
Primary | Serum concentrations of OPG (pg/ml) | Bone formation marker | 8 weeks | |
Primary | Serum concentrations of CTX (ng/ml) | Bone resorption marker | 8 weeks | |
Primary | Serum concentrations of TRAP (ng/ml) | Bone resorption marker | 8 weeks | |
Primary | Serum concentrations of RANKL (pg/ml) | Bone resorption marker | 8 weeks | |
Primary | Plasma concentrations of irisin (ng/ml) | Plasma concentrations of pro-and-anti-inflammatory cytokines | 8 weeks | |
Primary | Plasma concentrations of IL-6 (pg/ml) | Plasma concentrations of pro-and-anti-inflammatory cytokines | 8 weeks | |
Primary | Plasma concentrations of IL-10 (pg/ml) | Plasma concentrations of pro-and-anti-inflammatory cytokines | 8 weeks | |
Primary | Plasma concentrations of TNF-alpha (pg/ml) | Plasma concentrations of pro-and-anti-inflammatory cytokines | 8 weeks | |
Primary | Plasma concentrations of CRP (pg/ml) | Plasma concentrations of pro-and-anti-inflammatory cytokines | 8 weeks | |
Primary | Plasma concentration of creatine kinase (U/L) | Muscle damage | 8 weeks | |
Secondary | Serum concentration of IGF-1 (pg/ml) | Serum concentration of IGF-1 | 8 weeks | |
Secondary | Plasma concentration of TBARS | Oxidative stress | 8 weeks | |
Secondary | Plasma concentration of ROS | Oxidative stress | 8 weeks | |
Secondary | Saliva concentrations of cortisol (ug/dl) | Endocrine response | 8 weeks | |
Secondary | Saliva concentrations of testosterone (pg/ml) | Endocrine response | 8 weeks | |
Secondary | Oxidative stress | Plasma concentrations of markers of oxidative stress | 8 weeks |
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