Inflammatory Response Clinical Trial
Official title:
Randomized, Double-blind, Pilot Study on the Effect of Intravenous Ibuprofen on Inflammatory Responses in Patients Undergoing Surgery With General Anesthesia: Correlation With Clinical Outcomes
The administration of anti-inflammatory drugs such as ibuprofen before and after surgery has not been studied extensively. Subjects are being asked to participate in this study because they are scheduled for surgery and because the investigators want to study ways to improve recovery from surgery. Ibuprofen will be given several times before and after surgery. The investigators will ask questions to determine recovery and the investigators will draw blood to determine inflammatory response.
Human and animal studies suggest cyclooxygenase-inhibitors (COX-inhibitors) decrease the
production of inflammatory mediators. Studies also suggest that COX inhibitors attenuate
increases in corticosterone and eicosanoid levels after endotoxin injection. COX inhibitors
also appear to have anticancer effects, inhibiting angiogenesis, tumor growth, and metastatic
burden. These results suggest a role for IV ibuprofen in preventing untoward inflammatory
responses, shortening post-surgical convalescence, improving patient satisfaction, and
reducing the rate of complications occurring during the recovery from surgery. However, there
are no studies that have evaluated the relationship between administration of IV ibuprofen,
ensuing immunomodulation, and long-term outcomes.
Study Objective. The aim of the proposed study is to examine the effect of intravenous(IV)
ibuprofen on the inflammatory response in major surgery. More importantly, the investigators
will correlate changes in the concentration of inflammatory mediators with meaningful
clinical outcomes.
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