Inflammatory Bowel Diseases Clinical Trial
Official title:
Herbal Medicine for Inflammatory Bowel Diseases: a Development of Pattern Identification Algorithm by Retrospective Analysis of Case Series Data
NCT number | NCT04296500 |
Other study ID # | KyungheeU |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | November 1, 2007 |
Est. completion date | October 28, 2015 |
Verified date | March 2020 |
Source | Kyunghee University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study aimed to identify inflammatory bowel disease (IBD) patterns based on presenting symptoms and to suggest algorithms for determining pattern and herbal prescriptions for corresponding patterns. The investigators collected symptom data of 67 IBD patients who achieved and maintained clinical remissions after they had taken herbal medicine prescriptions. Prescriptions were categorised into 5 patterns, which were named after main features and symptoms of included patients. Associations between presenting symptoms and patterns were visualised using a term frequency inverse document frequency (TF-IDF) method. Determining IBD patterns from symptoms of patients was analysed and charted by decision tree modeling.
Status | Completed |
Enrollment | 67 |
Est. completion date | October 28, 2015 |
Est. primary completion date | February 28, 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 15 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of IBD by gastroenterologist - Patients have achieved and maintained clinical remission of IBD symptoms after they took herbal prescriptions - Patients have provided written informed consent Exclusion Criteria: - Details regarding any of 25 symptoms were omitted |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Acupuncture & Meridian Science Research Centre | Seoul |
Lead Sponsor | Collaborator |
---|---|
Hyangsook Lee, KMD, PhD |
Korea, Republic of,
Abitbol V, Lahmek P, Buisson A, Olympie A, Poupardin C, Chaussade S, Lesgourgues B, Nahon S. Impact of complementary and alternative medicine on the quality of life in inflammatory bowel disease: results from a French national survey. Eur J Gastroenterol Hepatol. 2014 Mar;26(3):288-94. doi: 10.1097/MEG.0000000000000040. — View Citation
Bernstein CN, Fried M, Krabshuis JH, Cohen H, Eliakim R, Fedail S, Gearry R, Goh KL, Hamid S, Khan AG, LeMair AW, Malfertheiner, Ouyang Q, Rey JF, Sood A, Steinwurz F, Thomsen OO, Thomson A, Watermeyer G. World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis. 2010 Jan;16(1):112-24. doi: 10.1002/ibd.21048. — View Citation
Lee MS, Lee JA, Alraek T, Bian ZX, Birch S, Goto H, Jung J, Kao ST, Moon SK, Park B, Park KM, You S, Yun KJ, Zaslawski C. Current research and future directions in pattern identification: Results of an international symposium. Chin J Integr Med. 2016 Dec;22(12):947-955. Epub 2014 Jun 18. — View Citation
Liu B, Zhou X, Wang Y, Hu J, He L, Zhang R, Chen S, Guo Y. Data processing and analysis in real-world traditional Chinese medicine clinical data: challenges and approaches. Stat Med. 2012 Mar 30;31(7):653-60. doi: 10.1002/sim.4417. Epub 2011 Dec 9. — View Citation
Panaccione R, Rutgeerts P, Sandborn WJ, Feagan B, Schreiber S, Ghosh S. Review article: treatment algorithms to maximize remission and minimize corticosteroid dependence in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2008 Sep 15;28(6):674-88. doi: 10.1111/j.1365-2036.2008.03753.x. Review. — View Citation
Yu F, Takahashi T, Moriya J, Kawaura K, Yamakawa J, Kusaka K, Itoh T, Morimoto S, Yamaguchi N, Kanda T. Traditional Chinese medicine and Kampo: a review from the distant past for the future. J Int Med Res. 2006 May-Jun;34(3):231-9. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Accuracy of pattern identification algorithm | Pattern identification algorithm was suggested using a decision tree method. Decision tree method was employed to explore the process of decision making on types of pattern based on clinical features of patients. | Oct 2015 |
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