Inflammatory Bowel Diseases Clinical Trial
Official title:
Differential EBI2 Expression Upon Allelic Status of the rs9557195 Polymorphism
EBI2 is a risk gene for inflammatory bowel diseases (rs9557195). Patients of the Swiss IBD cohort study have been genotyped for the allelic status of EBI2. The investigators will test the influence of rs9557195 genoty (TT or CC allel), inflammatory activity and current treatment (infliximab vs. vedolizumab) on expression and activity of EBI2 on blood lymphocytes, mRNA expression of EBI2 and UBAC2 (located on the opposite DNA strand of EBI2) and activity of lymphocytes on a migraton assay.
Status | Recruiting |
Enrollment | 340 |
Est. completion date | December 1, 2018 |
Est. primary completion date | December 1, 2018 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patient with IBD OR healthy volunteer - No major uncontrolled medical/ surgical/ psychiatric condition requiring ongoing management besides IBD in the respective study groups. Well controlled conditions (i.e. medically controlled arterial hypertension, occupational asthma) may be present Exclusion Criteria: none |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital Zurich | Zurich |
Lead Sponsor | Collaborator |
---|---|
University of Zurich |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | EBI2 expression - dependent on rs9557195 allele status (FACS) | EBI2 levels in PBMCs will be determined by FACS, and compared according to allele status of rs9557195 | at time of inclusion into the study | |
Secondary | EBI2 expression - dependent on rs9557195 allele status (RT-PCR) | EBI2 levels in PBMCs will be determined by RT-PCR, and compared according to EBI2 levels in PBMCs will be determined by RT-PCR, and compared according to allele status of rs9557195 | at time of inclusion into the study | |
Secondary | UBAC2 expression - dependent on rs9557195 allele status (RT-PCR) | UBAC2 levels in PBMCs will be determined by RT-PCR, and compared according to 2 levels in PBMCs will be determined by RT-PCR, and compared according to allele status of rs9557195 | at time of inclusion into the study | |
Secondary | Motility of PBMCs dependent on rs9557195 allele status (Boyden chamber) | motility of PBMCs will be assessed using the Boyden chamber and compared according to allele status of rs9557195 | at time of inclusion into the study | |
Secondary | EBI2-expression (FACS) in individuals treated with infliximab vs. vedolizumab | We will compare EBI2 expression as determined by FACS in individuals with infliximab and vedolizumab treatment | at time of inclusion into the study | |
Secondary | EBI2-expression (FACS) according to gut inflammation | We will compare EBI2 expression (determined by FACS) in IBD patients with severe disease, in remission and in healthy volunteers | at time of inclusion into the study |
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