Inflammatory Bowel Diseases Clinical Trial
Official title:
Microbiome and Genetic Analysis of Family Members With Inflammatory Bowel Disease
Inflammatory bowel disease(IBD) is a chronic inflammatory condition for gastrointestinal
tract.
Regarding its pathogenesis, there has been numerous studies to reveal the complex association
between genetic and environmental factors.
In Korea, the incidence of IBD is growing rapidly but genetic studies solely including
patients with Korean descent were not sufficient enough.
Therefore, the investigators planned to conduct genetic and fecal microbial analysis for the
60 individuals from 30 Korean IBD families to find out the pathogenesis of IBD.
Under the hypothesis that more risk variants will be observed among the familial IBD patient
than in IBD patients without any other affected family members, the investigators designed
genetic and fecal microbiome analysis for 60 patients form 30 families.
After extracting the DNA from blood samples, whole genome sequencing will be performed and
data will be comprared with the previously reported variances. Novel variances or incidence
of specific variances will be measured.
Genome-wide single nucleotide polymorphism array using Immunochip will be performed to search
common genetic variants and to calculate genetic risk score of IBD.
In this study, fecal microbiome is a surrogate marker for the enviromental aspect of
pathogenesis of IBD. The investigators assumed that family members are sharing similar mode
of lifestyle therefore we're presumed that their fecal microbial composition is alike.
Comparing genetic and microbial datas altogether with the data from unaffected family
member(Healthy internal control), investigators expecting to explain the genetic and
enviromental aspect of IBD pathogenesis.
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