Inflammatory Bowel Diseases Clinical Trial
Official title:
Immunological Characteristics of Patients With Primary Immunodeficiencies and Inflammatory Bowel Diseases
The investigators wish to characterize alterations in the architecture and function of immune cells in patients with a primary immunodeficiency that also develop inflammatory bowel disease. In addition, The investigators' goal is to characterize the microbiome of these patients, in order to determine whether specific microbial alterations are related to inflammation.
The pathogenesis of inflammatory bowel diseases (IBD), like Crohn's disease and ulcerative
colitis is complex and is thought to be related to genetic, environmental and microbial
alterations that lead to a hyperactive/dysregulated immune system that mediates tissue
damage. In rare cases, IBD can develop in patients with primary immunodeficiencies (PID) who
develop severe, atypical or recurrent infections. The bowel disease in these patients can
present after they develop infectious complications but also prior to that. The goal of the
current study is to characterize immune function in patients with PID and IBD in order to
identify alterations in pro-inflammatory and regulatory pathways.
The investigators will obtain blood samples from PID patients with IBD in order to perform
deep immune profiling using various techniques such as flow cytometry, ELISA and others.
Moreover, the investigators wish to characterize the microbiome of these patients. This
multi-disciplinary approach will advance our understanding why specific patients with an
immunodeficiency develop an IBD-like phenotype.
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