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Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis — REMOVE  

Infective Endocarditis Clinical Trial

Official title:
Revealing Mechanisms and Investigating Efficacy of Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis - a Multicentric Randomized Controlled Group Sequential Trial

Clinical Trial Summary

Infective endocarditis (IE) is associated with high hospital mortality for various reasons; one of them is circulatory failure in patients who undergo cardiac surgery for IE. One discussed reason underlying circulatory failure during surgery is the release of vasodilatatory mediators and cytokines. This study examines the efficacy and safety of a hemoadsorption filter which is approved for the reduction of the concentration of cytokines in the bloodstream.

Clinical Trial Description

The investigators assume a common standard deviation of 3.8 points and that a 1.4-point lower SOFA score in the Intervention Group is of clinical relevance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03266302
Study type Interventional
Source Jena University Hospital
Contact
Status Completed
Phase N/A
Start date January 17, 2018
Completion date December 31, 2020
View Details
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