Dose Optimization of Rivaroxaban Combined With Rifampicin

Status Recruiting

Clinical Trial Summary

The goal of this observational study is to learn about exposure levels of rivaroxaban at different doses in patients with prosthetic joint infection combined with the use of rifampicin. Participants will be collected blood samples to determine rivaroxaban plasma concentration. The main question it aims to answer is to predict the dose adjustment of rivaroxaban combined with the use of rifampin.

Clinical Trial Description

This study is a prospective observational study and does not interfere with the normal clinical diagnosis and treatment process. In the case of patients with periprosthetic infection with or without rifampicin, the blood concentration of rivaroxaban was monitored, and the data were further predicted and analyzed by statistical tests and physiological pharmacokinetic models, and suggestions were made for dose optimization. ;

Study Design

Related Conditions & MeSH terms

Infections

Clinical Trial Details

NCT number	NCT05658042
Study type	Observational
Source	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact	Ruijuan Xu
Phone	+8613851502360
Email	jean0129@163.com
Status	Recruiting
Phase
Start date	July 1, 2022
Completion date	June 30, 2025

View Details

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