Cerebrospinal Fluid (CSF) Pharmacokinetics of Antimicrobials in Children

Status Completed

Clinical Trial Summary

The purpose of this study is to learn more about antimicrobials, especially drug levels in the CSF that would normally be used in young children as part of standard care. These drugs are approved by the Food and Drug Administration (FDA) for treating infections. They are used extensively in children in the United States, but they have not been extensively studied in children or babies. The investigators do not have very much information on how children and babies handle these drugs; that is, how long it takes for the drugs to be removed from the blood circulation and to pass out of the body and how much goes into the central nervous system. The investigators also do not have good information to guide how often the investigators should give the drugs to children and babies to get the maximum effect on infections with the minimum amount of drug. Thus, the investigators will collect more information about how these drugs should be used in children and babies by doing this drug levels research study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Infections

Clinical Trial Details

NCT number	NCT00991185
Study type	Observational
Source	Duke University
Contact
Status	Completed
Phase
Start date	July 2009
Completion date	April 2014

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06055777` - Study of the Safety, Tolerability, and PK of SZEY-2108 Administered Intravenously to HVs in SAD and MAD Cohorts	Phase 1
Recruiting	`NCT05578196` - Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections.	N/A
Recruiting	`NCT05793983` - S100A8/A9 and Innate Immunity in Liver Disease
Active, not recruiting	`NCT05963269` - The Effect of the Game on Students' Intramuscular Injection Skills	N/A
Not yet recruiting	`NCT06026852` - Validation of Betalactam ML Prediction Models - TDMAide	N/A
Not yet recruiting	`NCT02222779` - Quantification of Transition Metals	N/A
Completed	`NCT01976234` - Stored RBC Transfusion and Immonomodulation	N/A
Completed	`NCT01530763` - Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)	Phase 2/Phase 3
Completed	`NCT02345135` - Susceptibility to Infections in Ataxia Telangiectasia	N/A
Completed	`NCT01158560` - A Trial of Vitamin D and Health Advice for the Prevention of Upper Respiratory Tract Infections	Phase 3
Completed	`NCT01176786` - Reusable Versus Disposable Draping System in Breast Reconstruction Surgery	N/A
Active, not recruiting	`NCT05284097` - Ad26.ZEBOV, MVA-BN-Filo Vaccination in Children and Adults Previously Vaccinated With Control in the EBOVAC-Salone Study	Phase 2
Enrolling by invitation	`NCT06055712` - Antibiotic Prophylaxis in Pediatric Open Fractures	Phase 4
Not yet recruiting	`NCT06338345` - Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients	N/A
Not yet recruiting	`NCT06402292` - Surgical Treatment of Osteoarticular Infections Using Bioactive Bone Substitute	N/A
Recruiting	`NCT06002685` - Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention	N/A
Completed	`NCT02802059` - E. Coli Nissle 1917 - Suspension for Infection Prophylaxis	Phase 3
Completed	`NCT05289674` - The Effect of Lactoferrin in High Calorie Formula on IL-6 and IL10 in Children With Failure to Thrive and Infection	N/A
Recruiting	`NCT05770765` - Creation of a Bank of Biological Materials and Associated Data Related to Patients With Infectious and Tropical Diseases
Completed	`NCT05389540` - Rural South and Southeast Asia Household Health Survey