COVID-19 - SARS-CoV-2 Community Contamination in Children and Adults - Impact of Variants (Dyn3CEA - Nosocor Phase 2)

Infection Viral Clinical Trial

Official title:

Epidemiology of CoV-2 SARS Infections: Dynamics of Community Contamination in Children and Adults - Impact of Variants

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04924842
• Other study ID #: 69HCL21_0564
• Status: Completed
• Start date: June 22, 2021
• Est. completion date: October 28, 2021

Study information

• Verified date: January 2022
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Unlike other respiratory viruses such as influenza and RSV where the child is the essential reservoir and central vector of intrafamilial contamination, the child is likely to be a small player in the transmission of CoV2-CoRSA infection. This study aims to describe the age category of the first contact, within 14 days before the appearance of the first symptoms of the index case in order to describe the age categories of this first contaminant, globally, in the group of children and finally in the group of adults. This work is intended to provide food for discussion and to justify the distancing and containment measures imposed on children when their isolation has a deleterious impact that has now been established for some children.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 87
• Est. completion date: October 28, 2021
• Est. primary completion date: October 28, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• 1) Children hospitalized in the Pediatric department of the Hospices Civils de Lyon with PCR positive for a variant of the historical SARS-CoV2, 2) Adults hospitalized in the the Hospices Civils de Lyon, for a Covid-19 disease with documented infection by a variant of the SARS-CoV-2 and included in the NOSO-COR study with matching criteria described below.

Exclusion Criteria:

1. Any patient suspected of nosocomial infection.

2. Any patient death during the Covid-19 infection.

3. Any adult patient without children living home.

4. Opposition to participate.

Related Conditions & MeSH terms

• Infection Viral
• Infections
• Virus Diseases

Intervention

Other:
• Review of medical file
Review of medical patient file, including patient tracing, brief summary of the disease course, barrier gestures, social distancing.
• Phone call interview
less than 15 minutes phone call

Locations

Country	Name	City	State
France	Hôpital Femme Mère et enfant	Lyon	Auvergne Rhône Alpes

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of possible contaminants, adults, adolescents and children with Covid-19	To describe the age category of the 1st possible contaminant in the index case to show the preponderance of possible adult and adolescent contaminants in the SARS-Cov-2 contamination.; Primary endpoint: Percentage of possible contaminants, adults, adolescents and children, in matched children and adults with Covid-19.	At inclusion