Genetic Studies in Patients and Families With Infantile Spasms

Infantile Spasms Clinical Trial

Official title:

Genetic Studies in Patients and Families With Infantile Spasms

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01723787
• Other study ID #: 12-0482
• Status: Completed
• Start date: March 2013
• Est. completion date: November 30, 2018

Study information

• Verified date: June 2021
• Source: University of Colorado, Denver
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Infantile spasms (IIS), a characteristic epilepsy syndrome of infancy with often catastrophic developmental consequences, is known in some patients to have many different genetic, metabolic and structural etiologies. However, for most patients IIS is the only presenting clinical feature and the specific cause is unknown. Only two FDA approved pharmacologic treatments for IIS exist, Adrenocorticotropic hormone (ACTH) and vigabatrin. While vigabatrin may be the treatment of choice for Tuberous Sclerosis as a cause for IS, ACTH is the treatment of choice for all others. Unfortunately, a substantial number of patients may still not respond to ACTH and there is no a priori way that suggests which patients may be responders. This has led to the following key questions:

Can novel genetic analyses determine known genetic causes of IS with greater efficiency (more timely and cost-effective)? Can novel genetic analyses determine previously unknown disease modifying genes that predispose individuals to develop IS? Can novel genetic analyses elaborate genes and gene polymorphisms that favor ACTH responsiveness? Do these polymorphisms suggest strategies to improve ACTH responsiveness?

Description:

Primary Aim 1: Apply whole-exome sequencing to determine possible causes of cryptogenic IS and evaluate adding whole-exome sequencing to standard practice for determining causes of IS. Sub-aim 1: Determine the effectiveness of whole-exome sequencing in suggesting disease-modifying genes that may contribute to triggering IS.

Primary Aim 2: Determine genes, through whole-exome sequencing, that may play a role in determining ACTH responsiveness for IS. Sub-aim 2: Correlate genes or genetic factors (haplotypes) associated with ACTH responsiveness and disease modification.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 63
• Est. completion date: November 30, 2018
• Est. primary completion date: March 9, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 31 Days to 21 Years

Eligibility

Inclusion Criteria:

• Patient trios (both biological parents + patient with IIS = trio) with IIS retrospectively identified to have been treated with ACTH according to FDA-approved protocol (Table 1).

• Ability to provide informed consent (in case of severe to profound intellectual disability, consent provided by an legally authorized representative, as necessary)

Exclusion Criteria:

• IIS due to suspected or genetically proven tuberous sclerosis

• IIS but do not meet retrospective enrollment criteria (Table 1)

• Inability to complete consent process

Related Conditions & MeSH terms

• Infantile Spasms
• Spasm
• Spasms, Infantile

Locations

Country	Name	City	State
United States	Children's Hospital Colorado	Aurora	Colorado

Sponsors (1)

Lead Sponsor	Collaborator
University of Colorado, Denver

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Determine the effectiveness of novel genetic analyses in suggesting disease-modifying genes that may contribute to triggering IIS.	Apply novel genetic analyses to determine possible causes of cryptogenic IIS and evaluate adding novel genetic analyses to standard practice for determining causes of IIS	Results of the DNA studies will be evaluated prior to completion of the 5th year to assess the need for further investigations.
Secondary	Determine genes, through novel genetic analyses, that may play a role in determining ACTH responsiveness for IIS	Correlate genes or genetic factors (haplotypes) associated with ACTH responsiveness and disease modification	Results of the DNA studies will be evaluated prior to completion of the 5th year to assess the need for further investigations