Clinical Trials Logo

Clinical Trial Summary

This study aims at recruiting about twenty very low birth weight infants, either intrauterine growth restricted (IUGR) or NON-IUGR

STRATIFICATION:Population will be stratified in two groups: IUGR infants (approximately 10 children) and NON-IUGR infants (approximately 10 children).

PRIMARY ENDPOINT:To evaluate the changes in the intestinal perfusion determined by feeding in VLBW infants fed by 3 hours nasogastric nutrition (CN) or by bolus (BN).

SECONDARY ENDPOINT:

- To compare if changes in the intestinal perfusion induced by feeding are different between IUGR and NON-IUGR infants;

- To compare growth and nutritional status of the 2 groups by randomized arm.

- To evaluate if changes of intestinal perfusion and oximetry induced by feeding are related to baseline (< 72 hours of life) values of Doppler flow velocimetry and of Near Infrared Spectroscopy (NIRS). After birth, in the first 24 hours of life, and in the transitional period, between the 48th and 72nd hours of life, all infants' intestinal perfusion will be evaluated with NIRS and a doppler of the superior mesenteric artery will be executed.

- To test if changes in intestinal oximetry and perfusion can be reliable predictors of feeding intolerance (need of interruption of enteral feeding).

DESIGN: This is a randomized, non-pharmacological, single-center, cross-over study including 20 VLBW babies. Duration of the study: 24 months.

INCLUSION CRITERIA

- Weight at birth ranging: 700 - 1501 grams;

- Gestational age up to 25 weeks and 6 days;

- Written informed consent from parents or guardians

EXCLUSION CRITERIA

- Major congenital abnormality (severe heart or cerebral disease, chromosomopathies, severe renal malformations, any malformation or disease of the gastroenteric tract)

- Significant multi-organ failure prior to trial entry (perinatal asphyxia with renal, cardiac or cerebral impairment, DIC)

- Pre-existing cutaneous disease not allowing the placement of the probe


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01341236
Study type Interventional
Source San Gerardo Hospital
Contact
Status Completed
Phase Phase 4
Start date September 2011
Completion date March 2013

See also
  Status Clinical Trial Phase
Completed NCT02913677 - Prolonged Minimal Enteral Nutrition Versus Slowly Advancing Enteral Nutrition in Very Low Birth Weight Infants: N/A
Completed NCT02379728 - Ghana PrenaBelt Trial: A Positional Therapy Device to Reduce Still-Birth N/A
Completed NCT05217186 - Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
Completed NCT03082313 - Movement-based Infant Intervention N/A
Terminated NCT01430832 - Developmental Outcomes of Extreme Prematurity, 5-15 Years Postpartum
Completed NCT02583776 - Continuous Glucose Monitoring and Preterm Infants Phase 4
Terminated NCT02599545 - Testosterone and Cortisol Levels in Infants
Active, not recruiting NCT01809548 - Preterm Infants on Early Solid Foods N/A
Completed NCT01363167 - Identifying Vitamin D Deficiency in Very Low Birth Weight Infant (VLBW) Infants Part 2 N/A
Completed NCT02078687 - Growth, Risks of Allergy and Metabolic Syndrome in 6 Year Old Children Born Preterm Compared to Postdischarge Nutrition N/A
Completed NCT01193270 - Vitamin E for Extremely Preterm Infants Phase 1
Completed NCT00760942 - Liquid Preterm Formula Versus Powdered Human Milk Fortifier in VLBW Infants N/A
Completed NCT02280031 - Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial. Phase 2
Completed NCT01717625 - The Efficacy and Safety of Montelukast Sodium in the Prevention of Bronchopulmonary Dysplasia Phase 2
Completed NCT00601081 - Human Milk Fortifier and Cytokine Profile N/A
Completed NCT00009646 - Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP) Phase 3
Completed NCT00579943 - Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants N/A
Completed NCT02389478 - Oropharyngeal Administration of Colostrum to Very Low Birth Weight Infants N/A
Recruiting NCT02016638 - Sleep Quality in Pregnancy and Its Impact on Pregnancy Outcomes N/A
Terminated NCT01799629 - Efficacy of Prophylactic Glycerin Suppositories for Feeding Intolerance in Very Low Birth Weight Preterm Infants: a Randomized Trial N/A