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Clinical Trial Summary

The main objective of this research is to study the links between changes in the intestinal microbiota (in terms of diversity) during the first 6 weeks of life for preterm infants and the presence / absence of a TH1 immune status at 36 months of age.


Clinical Trial Description

The secondary objectives are to study the links between changes of the intestinal microbiota premature infants in terms of: - changing diversity of the microbiota in the first 6 weeks of life; - changes in the bacterial community (UniFrac study) during the first 6 weeks of life; - diversity of the microbiota up to 6 weeks; -AND- - diversity of the microbiota at 1, 2 & 3 years; - bacterial communities (UniFrac study) at 1, 2 & 3 years; - lymphocyte subpopulation profiles at 3 years; - serum immunoglobulin A, G, M, E levels at 3 years; - history of infectious episodes, allergic and inflammatory episodes during the first 3 years of life. The links between certain variables known in the literature and neonatal microbiota will be confirmed / studied in our population: - mode of delivery; - length (and type) of antibiotic therapy in the neonatal period; - duration of breastfeeding. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02738411
Study type Observational
Source Centre Hospitalier Universitaire de Nimes
Contact
Status Active, not recruiting
Phase
Start date May 12, 2017
Completion date June 30, 2024

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