Infant, Premature Clinical Trial
Official title:
Observational Study on the Effects of Enteral Feeding and Feeding Methods on Respiratory Pattern as Assessed by Diaphragm Electrical Activity (EAdi) in Very Low Birth Weight Preterm Infants
In this study, we want to see how feeding affects breathing in small premature babies. Using a special feeding tube in the stomach, we can measure how the diaphragm (a large breathing muscle) might be affected by feeding. We also want to see if slowing down the feeding may lessen this effect.
Premature babies may have pauses in breathing known as apnea, which may require invasive
treatment. The exact cause of apnea is unknown, and may be related to a combination of
brain, gut, and lung immaturity.
Research in premature babies suggests that feeding may affect lung functions, but such
effects may be lessened if feeds are given at a slower rate. Further research showed that
the diaphragm, an important breathing muscle, may be fatigued by a full stomach. We
speculate that, in premature babies, feeding might tire the diaphragm, thus impairing lung
function and possibly causing apnea.
We plan to study 10 stable premature babies less than 23 weeks and 1.25 kilograms at birth.
By inserting a special feeding tube with sensors into the stomach, we can measure the
electrical activity of the diaphragm (EAdi). By analysing EAdi before and after feeding, we
want to directly measure how feeding might affect lung functions. We also want to compare
feeding at the usual rate (5-15 minutes) versus a slower rate (90 minutes) to see how their
effects on lung functions might differ.
This important study will help us determine the most appropriate treatment for premature
babies with apnea related to feeding.
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Observational Model: Case-Crossover, Time Perspective: Prospective
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