Individuality Clinical Trial
Official title:
Genetic & Environmental Determinants Of Immune Phenotype Variance: Establishing A Path Towards Personalized Medicine
The purpose of this study is to assess the determinants of immunologic variance within the general healthy population.
Susceptibility to infections, disease severity, and response to medical therapies and
vaccines are highly variable from one individual to another. While the question of variance
in human populations continues to be a focal point of scientific research, medical practices
and public health policies typically take a 'one size fits all' model to disease management
and drug development.
Individual heterogeneity in the immune response can have an enormous impact on the
likelihood to respond to therapy or the development of side effects secondary to vaccine
administration. Because of the complexity of immune responses in the individual and within
the population, it has not been possible thus far to define the parameters (genetic or
environmental) that constitute a healthy immune system and its natural occurring
variability.
Efforts to restore the 'personal' in medical care are the current challenge, and the driving
vision of the project, to which the current study belongs.
In order to realize the promise of personalized medicine, an in-depth understanding of the
determinants of heterogeneity in host response to stress is required.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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