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Characterization of Intestinal Microbiota in Children With Inborn Errors of Metabolism (IEM) — IEM  

Inborn Errors of Metabolism Clinical Trial

Official title:
Enterobacteria Strain-level Characterization in Children With Inborn Errors of Metabolism (IEM)

Clinical Trial Summary

Study around children with inborn errors of metabolism (IEM) and their healthy siblings. Collection of stool and urine to assess contribution of microbiota to disease severity.

Clinical Trial Description

This study aims to collect biological samples (stool and urine) from children with inborn errors of metabolism, IEM (like UCD (urea cycle disorder), PA (propionic aciduria) and MMA (methylmalonic aciduria) and their healthy siblings. The main focus of the study is to assess the contribution of the intestinal microbiota to disease severity in children that suffer from different forms of IEM and potentially find microbiota targets that could be used in the design of therapeutic/prophylactic agents. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05330039
Study type Observational
Source ETH Zurich
Contact
Status Completed
Phase
Start date November 30, 2021
Completion date February 27, 2024
View Details
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