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NCT02626702 Clinical Trial

Immune Modulators and IVF

In Vitro Fertilization Clinical Trial

Official title:
Immune Modulators in Women Undergoing IVF----a Prospective Study

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT02626702
Other study ID # 1502015953
Secondary ID
Status Terminated
Phase
First received
Last updated
Start date July 31, 2015
Est. completion date August 31, 2019

Study information
Verified date September 2019
Source Weill Medical College of Cornell University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Exploring the immune mediators of early pregnancy prospectively may help to identify new early interventions that will increase the likelihood of success and help women make informed decisions regarding their pregnancies.

Description:

Sera will be obtained from 500 women undergoing IVF at five time periods: cycle Day 2, post HCG, Day 24, Day 28, and/or Day 35.Aliquots of sera will be tested by commercial ELISA kits for concentrations of immune modulators suggestive to be predictive of IVF outcome, such as cytokines (interleukins, tumor necrosis factor, and interferon), neurotrophins (BDNF), protease inhibitors (HE4) and insulin-like growth factors (IGF-1, IGF-2, IGFBP). The results will be correlated with IVF outcomes.

Recruitment information / eligibility
Status Terminated
Enrollment 500
Est. completion date August 31, 2019
Est. primary completion date August 9, 2019
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 44 Years
Eligibility Inclusion Criteria:

- All fresh transfers

Exclusion Criteria:

- PGD

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Observational
Excess blood from subjects will be analyzed to explore the relationship between Immune Modulators and IVF outcomes.

Locations
Country Name City State
United States Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine New York New York

Sponsors (1)
Lead Sponsor Collaborator
Weill Medical College of Cornell University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary To explore the relationship between immune mediators and IVF outcome prospectively in women who receive in vitro fertilization treatment. 35 days
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