Impulsive Behavior Clinical Trial
Official title:
Modulating Decision-Making and Impulse Control With Transcranial Direct Current Stimulation (tDCS) Over the Orbitofrontal Cortex (OFC): A Randomized and Sham-Controlled Study
Verified date | October 2014 |
Source | Douglas Mental Health University Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Interventional |
In this study the investigators aim to assess whether transcranial direct current stimulation (tDCS; a safe and non-invasive method for modulating the activity of specific brain regions) when applied over the orbitofrontal cortex (OFC) is able to modulate decision-making and impulse control in healthy participants.
Status | Completed |
Enrollment | 45 |
Est. completion date | March 2014 |
Est. primary completion date | March 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Men or women aged 18 to 60 years Exclusion Criteria: - Presence any psychiatric and/or neurological illness - Psychoactive substance abuse/dependence in the past 6 months - Current use of medication(s) that might influence cognition and/or affective status - Presence of an uncontrolled medical disease (e.g., cardiovascular, renal) - Pregnancy and/or lactation - Specific contraindication for tDCS (e.g., metallic head implant). |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Canada | Neuromodulation Research Clinic, Douglas Mental Health University Institute | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Douglas Mental Health University Institute |
Canada,
Beeli G, Casutt G, Baumgartner T, Jäncke L. Modulating presence and impulsiveness by external stimulation of the brain. Behav Brain Funct. 2008 Aug 4;4:33. doi: 10.1186/1744-9081-4-33. — View Citation
Boggio PS, Campanhã C, Valasek CA, Fecteau S, Pascual-Leone A, Fregni F. Modulation of decision-making in a gambling task in older adults with transcranial direct current stimulation. Eur J Neurosci. 2010 Feb;31(3):593-7. doi: 10.1111/j.1460-9568.2010.07080.x. Epub 2010 Jan 25. — View Citation
Fecteau S, Pascual-Leone A, Zald DH, Liguori P, Théoret H, Boggio PS, Fregni F. Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk during ambiguous decision making. J Neurosci. 2007 Jun 6;27(23):6212-8. — View Citation
Hecht D, Walsh V, Lavidor M. Transcranial direct current stimulation facilitates decision making in a probabilistic guessing task. J Neurosci. 2010 Mar 24;30(12):4241-5. doi: 10.1523/JNEUROSCI.2924-09.2010. — View Citation
Sela T, Kilim A, Lavidor M. Transcranial alternating current stimulation increases risk-taking behavior in the balloon analog risk task. Front Neurosci. 2012 Feb 14;6:22. doi: 10.3389/fnins.2012.00022. eCollection 2012. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in the net score of the Iowa Gambling Task | Before and after a 30-minute tDCS session | No | |
Secondary | Change in the "average-adjusted number of pumps" in the Balloon Analog Risk Task | Before and after a 30-minute tDCS session | No | |
Secondary | Change in the number of risky choices in the Game of Dice Task | Before and after a 30-minute tDCS session | No | |
Secondary | Change in the number of commission errors in the Continuous Performance Task | Before and after a 30-minute tDCS session | No | |
Secondary | Change in the interference index in the Stroop Color-Word Test | Before and after a 30-minute tDCS session | No | |
Secondary | Change in the stop-signal reaction time in the Stop-Signal Task | Before and after a 30-minute tDCS session | No |
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