Implants Clinical Trial
Official title:
Analysis of Specimens From Patients With Orthopaedic Implants
The investigators aim to determine the cause of failure of orthopaedic implants using multi-disciplinary analysis of data from patients who have undergone revision.
The following tests will then be arranged:
- Tribological assessment. The investigators will measure the wear of the explants using:
1) 'out of roundness'; and 2) Coordinate measuring. Semi-quantitative assessment of
damage to the explants will also be conducted
- Histological assessment. Tissue sent in formalin may determine the biomarker of
diagnosis of metal ion synovitis where applicable
- Metal ion measurement in body fluids where applicable (in patients with metal implants)
- Diamond Light Source (this was approved in the 1st amendment). The tests will involve
subjecting formalin fixed tissue to the high energy electron beam of the Diamond Light
Source
- Destructive testing of the implant is allowed by the patient (after all non-destructive
tests have been performed)
- Protein analysis of fluid and tissue if provided
- Titanium levels from blood samples if provided
- Gene expression testing to assess and understand mechanism of inflammation where
applicable
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