Ridge Augmentation With Simultaneous Implant Placement Using Bone Blocks With Autogenous Tooth Graft

Implant Clinical Trial

Official title:

Ridge Augmentation With Simultaneous Implant Placement Using Xenogenic Blocks or Autogenous Bone Blocks With Autogenous Tooth Graft

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05407363
• Other study ID #: KFSIRB200-72
• Status: Completed
• Phase: N/A
• Start date: April 1, 2022
• Est. completion date: August 20, 2023

Study information

• Verified date: December 2023
• Source: Kafrelsheikh University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Autogenous bone, with its osteogenic, osteoinductive, and osteo-conductive characteristics has been used for bone grafts with optimal integration into host tissues. For this reason, autogenous bone has been often considered the gold standard of bone regeneration material. However, the amount of autogenous bone that may be harvested is limited, and the harvesting procedure is traumatic.

Bone substitutes, including allografts, xenografts, and alloplasts have been used successfully as alternatives to autogenous bone grafts in ridge augmentation procedures.

In 2008, autogenous tooth bone graft (ATG) was introduced and used for the first time as a bone grafting material for GBR. The tooth contents are extremely similar to that of the alveolar bone. The enamel inorganic, organic, and water contents are 95 percent, 0.6 percent, and 4 percent, respectively. However, in the dentin, the percentages are 70 to 75 percent, 20 percent, and 10 percent, respectively. They are 65 percent, 25 percent, and 10 percent, respectively, when compared to the alveolar bone content.

The aim of this study is to compare ridge augmentation using autogenous bone block (ABB) with immediate implant placement and filling the generated gap with autogenous bone graft (ABG) or ATG, or ridge augmentation using xenograft bone block (XBB) with immediate implant placement and filling the generated gap with ATG.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: August 20, 2023
• Est. primary completion date: August 12, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Teeth with buccal bone destruction by periodontal disease and need extraction (horizontal or vertical bone defect);

• Absence of acute inflammation;

• Absence of uncontrolled systemic illness that would preclude implantation;

• Good dental and systemic healthy conditions;

• Patients were willing and able to return for multiple follow-up visits.

Exclusion Criteria:

• Patients with systemic illnesses,

• psychological abnormalities,

• para-functional habit,

• smokers or alcoholics,

• pregnant and lactating patients,

• patients undergoing or recently completed radiotherapy or chemotherapy,

• patients on drugs affecting the healing process,

• patients with endodontically treated teeth

Related Conditions & MeSH terms

• Implant

Intervention

Procedure:
• ABB and ATG with simultaneous implant placement
Ridge augmentation using ABB and ATG as a graft material with simultaneous implant placement
• XBB and ATG with simultaneous implant placement
Ridge augmentation using XBB and ATG as a graft material with simultaneous implant placement
• ABB and ABG with simultaneous implant placement
Ridge augmentation using ABB and ABG as a graft material with simultaneous implant placement

Locations

Country	Name	City	State
Egypt	Faculty of Dentistry, Kafrelsheikh University	Kafr Ash Shaykh

Sponsors (1)

Lead Sponsor	Collaborator
Kafrelsheikh University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical evaluation probing pocket depth and amount of bone around simultaneously placed dental implants	Changes on pocket depth and amount of bone using ABG or ATG with ABB or XBB around simultaneously placed dental implants	9 months
Primary	radiographic outcome measuring the amount of bone around simultaneously placed dental implants	the radiographic outcome by measuring the amount of bone by using ATG or ABG on bone formation with ABB or XBB around simultaneously placed dental implants	9 months