The Effect of Hyaluronic Acid Gel on Relieving Post-Implantation Pain

Implant Complication Clinical Trial

Official title:

Evaluation of the Efficacy of a Hyaluronic Acid Gel in Relieving Post-Implantation Pain: A Split-Mouth Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05776290
• Other study ID #: UDDS-OralMed-01-2023
• Status: Completed
• Phase: N/A
• Start date: February 15, 2021
• Est. completion date: May 15, 2022

Study information

• Verified date: April 2023
• Source: Damascus University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Few previous studies have employed HA in the implant socket; instead, the majority have applied it topically to the area around dental implants after they have been placed. The application was done after suturing in these investigations. Therefore, the goal of the current study was to inject HA into the implant socket and onto the alveolar bone prior to implant insertion and suturing in order to preserve the HA for an extended period of time.

This study aims to use a visual analog scale (VAS) on the first, third, and tenth days following the surgical intervention to assess the efficacy of employing HA in dental implants in terms of pain reduction that may accompany dental implant surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: May 15, 2022
• Est. primary completion date: March 15, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• bilateral tooth loss with a sufficient amount of bone volume

• no general problems

• good oral health

• age between 20 and 60 years

Exclusion Criteria:

• the use of immunosuppressive drugs and corticosteroids for long periods

• the existence of serious systemic disorders

• contraindications for local anesthesia or oral surgery

• pregnant women and nursing mothers

• patients receiving chemotherapy or radiation

• alcoholics and heavy smokers.

Related Conditions & MeSH terms

• Implant Complication

Intervention

Biological:
• Hyaluronic Acid
This material will be injected into the prepared impact socket prior to inserting the implant. This injection will be done inside the socket as well as on the periphery of the socket.

Locations

Country	Name	City	State
Syrian Arab Republic	Department of Oral Medicine, Faculty of Dentistry, University of Damascus	Damascus

Sponsors (1)

Lead Sponsor	Collaborator
Damascus University

Country where clinical trial is conducted

Syrian Arab Republic, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in the Perception of pain	This will be measured using a numeric rating scale. Patients will be asked to indicate the level of pain they perceive on a scale from 1 to 10. The intensity of pain is going to be classified according to the following categories: 0 = no pain, 1-3 = mild pain, 3-6 = moderate pain, and 6-10 = severe pain.	First assessment: at 24 hours following the surgical procedure. Second assessment: at 72 hours following the surgical intervention. Third assessment will be made on the tenth day following the surgical intervention