Clinical Trials Logo
  1. Home
  2. Impaired Cognition
  3. NCT03504501

Synaptic Plasticity and Cognitive Function in RASopathies — SynCoRAS  

Impaired Cognition Clinical Trial

Official title:
Improvement of Synaptic Plasticity and Cognitive Function in RAS Pathway Disorders

Clinical Trial Summary

The project is targeting cognitive impairment, one of the main health problems of patients with RAS pathway disorders. The aim of this study is to translate findings of animal studies to humans. This has been done by the applicants successfully for Lovastatin in Nf1. This result will be transferred to patients with Noonan Syndrome. lamotrigine is most likely a more effective and promising substance improving synaptic plasticity and consecutive cognitive function. It is expected that both substances are improving synaptic plasticity as well as alertness and changes in alertness may be a precondition for improvement of cognition.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03504501
Study type Interventional
Source Technical University of Munich
Contact
Status Terminated
Phase Phase 2
Start date March 22, 2019
Completion date October 31, 2023
View Details
See also
  Status Clinical Trial Phase
Completed NCT04006756 - A Study on Better Cognitive Functioning Through Braintraining on the Internet N/A
Active, not recruiting NCT02920632 - Cognitive Training in Parkinson Study N/A
Completed NCT01716975 - Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy Phase 3
Completed NCT01714661 - Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy Phase 3
Active, not recruiting NCT02182817 - Exposure to General Anaesthesia in Infancy and Neurocognitive Development
Completed NCT01713491 - Pre-stroke Cognitive Status and Thrombolytic Therapy N/A
Recruiting NCT01315704 - Alzheimer's Disease and Related Disorders N/A
Completed NCT01315717 - Gait and Alzheimer Interaction Tracking (GAIT) Study N/A
Completed NCT01006330 - Dysphagia in Elderly Medical Patients Phase 4
Completed NCT01818778 - The Efficacy of Using Volunteers to Implement a Cognitive Stimulation Program in Two Long-Term Care Homes N/A
Recruiting NCT01314638 - Study of Adherence and Effects of Balance Exercices (SIEL BLEU Associatio) N/A
Completed NCT01739933 - The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Phase 3
Completed NCT02936401 - Mindfulness Based Stress Reduction for Older Adults With HIV Associated Neurocognitive Disorders N/A
Terminated NCT03095170 - Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder N/A
Completed NCT02723318 - The Impact of Family Financial Support on Cognition N/A
Recruiting NCT02290834 - Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer N/A
Completed NCT03064308 - The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery N/A
Completed NCT02265757 - Behavioral Interventions to Prevent or Delay Dementia N/A
Completed NCT01714713 - A 26-Week Extension Study of EVP-6124 (Alpha-7 nAChR) as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy Phase 3
Recruiting NCT01490567 - A Double-blind, Placebo-controlled Trial of Donepezil Adjunctive Treatment for Cognitive Impairment in Schizophrenia Phase 4