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Influence of Pantoprazole on the Bioavailability of MMF and EC-MPS

Immunosuppression Clinical Trial

Official title:
Pharmacokinetic Cross-over Study to Evaluate the Influence of Pantoprazole on MPA Bioavailability Administered as Mycophenolate Mofetil and Enteric Coated Mycophenolate Sodium in Maintenance Renal Transplant Patients

Clinical Trial Summary

The objective of this pharmacokinetic study is to examine a possible drug-drug interaction of Pantoprazole on the bioavailability mycophenolic acid.

Clinical Trial Description

It is a randomized open-label 4-sequence 4-period pharmacokinetic cross-over study. The objective of the pharmacokinetic study is to examine a drug-drug interaction of pantoprazole on the bioavailability mycophenolic acid administered as either mycophenolate mofetil (Cellcept(R) or mycophenolate Sodium; EC-MPS (Myfortic (R) in stable renal allograft recipients under maintenance immunosuppressive therapy (cyclosporine +/- low dose glucocorticoids). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01801280
Study type Interventional
Source Charite University, Berlin, Germany
Contact
Status Completed
Phase Phase 4
Start date January 2012
Completion date March 2014
View Details
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