Immune Thrombocytopenia Clinical Trial
Official title:
Combination of Fixed Low-dose Eltrombopag and rhTPO for Treatment of Immune Thrombocytopenia
This is a prospective, single-arm study to investigate the efficacy and safety of the combination of fixed low-dose eltrombopag plus recombinant human thrombopoietin (rhTPO) as treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) patients during the COVID-19 pandemic.
Eltrombopag, a small molecule agonist of thrombopoietin receptor (TPO-RA), was recommended as
the subsequent treatment for ITP patients, which also already showed robust
efficacy.Recombinant human thrombopoietin (rhTPO) is a full-length glycosylated-TPO produced
by Chinese hamster ovary cells, which showed its effectiveness in ITP in a variety of
studies.
Both eltrombopag and rhTPO demonstrated good safety in ITP patients. Because of their
non-immunosuppressive nature, both of them serve as a reasonable choice during the global
COVID-19 pandemic.
Since they increase the number of platelets through different mechanisms, and previous
studies demonstrated that they might exert synergic effect. The investigators hypothesized
that the combination of these two agents could be a promising option for treatment of
corticosteroid-resistant or relapsed ITP patients.
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