Immune Thrombocytopenia Clinical Trial
Official title:
The Combination of Terbutaline and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
Single-arm, open-label, single center study to assess the efficacy and safety of terbutaline plus danazol in patients with corticosteroid resistant/relapsed ITP.
Immune thrombocytopenia (ITP) is a severe bleeding disorder. Approximately 2/3 of patients
achieve remission from first-line therapies. However, the underlying mechanism of
corticosteroid-resistant or relapsed ITP is not well understood; thus, treatment remains a
great challenge. β2-AR agonist terbutaline modulates T cell differentiation and effector cell
function.
A single center prospective study was performed in non-splenectomized ITP patients who were
either resistant to a standard dose of corticosteroids or had relapsed. Patients were
assigned to terbutaline plus danazol group. Platelet count, bleeding and other symptoms were
evaluated before and after treatment. Adverse events are also recorded throughout the study,
in order to assess the efficacy and safety of terbutaline plus danazol in patients with
corticosteroid-resistant/relapsed ITP.
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