Immune Thrombocytopenia Clinical Trial
Official title:
Extended Platelet Parameters as a Means to Differentiate Immune Thrombocytopenia From Hypo-proliferative Thrombocytopenias.
To utilise extended platelet parameters in order to individuate Immune Thrombocytopenia
(ITP) from hypo-proliferative causes of thrombocytopenia.
To develop the clinical potential of the extended platelet parameters as they pertain to
distinguishing different causes of thrombocytopenia from one another.
To test the hypothesis that mean platelet component (MPC) and mean platelet mass (MPM) might
distinguish between thrombocytopenia related to bone marrow dysfunction and immune mediated
destruction of platelets.
Status | Completed |
Enrollment | 50 |
Est. completion date | October 2015 |
Est. primary completion date | October 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - All individuals age 18yrs and above capable of rendering consent - Known ITP confirmed by response to intravenous immune globulin (IVIG), glucocorticoids, or winRho and exclusion of all other possible causes of thrombocytopenia - Confirmed aplastic anemia [as assessed through bone marrow trephine biopsy] - Chemotherapy induced thrombocytopenia assessed at time of predicted nadir. Exclusion Criteria: - Suspected multifactorial thrombocytopenias and thrombocytopenia due to hypersplenism - Chronic active hepatitis - Those infected with HIV - Patients receiving concomitant radiotherapy - Gravid females - Congenital thrombocytopenias |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Roosevelt Hospital | New York | New York |
Lead Sponsor | Collaborator |
---|---|
Beth Israel Medical Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Platelet mass distribution width | 12 Months | No | |
Primary | Increased platelet density | 12 months | No | |
Secondary | mean platelet mass | 12 months | No |
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