Immune System Clinical Trial
Official title:
Dose Response Study of the Impact of a Yogurt Containing Bifidobacterium Lactis BB-12 and Lactobacillus Acidophilus LA-5 on the Immune System and Gut Health.
The purpose of this study is to determine the dose-response effect of a yogurt containing a combination of bifidobacterium Lactis (BB-12) and Lactobacillus Acidophilus (LA-5) and green tea extract on markers of the immune system and gut health in healthy subjects. We hypothesize that the response of the immune function will be dose-dependent of the probiotics found in the fermented yogurt.
There is an increasing list of food containing probiotics on the market. Several studies
have emphasized the health benefits of single probiotics, particularly on the immune system.
However, it is unclear how a combination of two different probiotics complemented with green
tea extract can beneficially modify markers of the immune.
The aim of this study is to determine the dose-response effect of a yogurt containing a
combination of bifidobacterium lactis (BB-12) and Lactobacillus Acidophilus LA-5 and green
tea extract on immune system in healthy subjects. More specifically, this randomized,
parallel placebo controlled study will investigate the impact of increasing doses (109 and
1010) of these probiotics on phagocytosis activity, oxidative metabolism and on the
antipneumococcics antibody specific serotype response S. pneumoniae vaccination. Finally,
this study will also examine the effect of increasing dose of these probiotics on intestinal
microflora and blood lipids.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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