Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05095129
Other study ID # 1192
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 23, 2022
Est. completion date January 20, 2023

Study information

Verified date March 2023
Source Asfendiyarov Kazakh National Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis


Recruitment information / eligibility

Status Completed
Enrollment 400
Est. completion date January 20, 2023
Est. primary completion date January 20, 2023
Accepts healthy volunteers
Gender All
Age group 4 Years to 40 Years
Eligibility Inclusion Criteria: 1. Persons with a doctor-confirmed diagnosis of idiopathic scoliosis; 2. Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs; 3. Hereditary history of scoliosis; 4. Persons who are able and willing to provide written informed consent; Exclusion Criteria: 1. Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age; 2. Representatives of the Kazakh ethnic group less than 3 generations; 3. No family history of bilateral idiopathic scoliosis; 4. Patients with an acute period of the inflammatory process (laboratory and clinical signs); 5. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; 6. Pregnant or lactating women; 7. Tuberculosis of any localization in the active phase and in history; 8. Severe and decompensated diseases of the liver and kidneys, cardiovascular system; 9. Severe and decompensated course of endocrine diseases; 10. Autoimmune diseases; 11. Systemic diseases; 12. Oncological diseases;

Study Design


Related Conditions & MeSH terms


Intervention

Genetic:
SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Locations

Country Name City State
Kazakhstan Scientific center of traumatology and orthopedics named after academician Batpenova ND Almaty

Sponsors (1)

Lead Sponsor Collaborator
Asfendiyarov Kazakh National Medical University

Country where clinical trial is conducted

Kazakhstan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Genotyping for the SNP associated with liver cirrhosis Genotype frequency of SNP in the study genes of participants and control participants. 1 year
See also
  Status Clinical Trial Phase
Completed NCT01795495 - Methadone vs Magnesium in Spinal Fusion Phase 2
Recruiting NCT04539522 - Efficacy of a Three-dimensionally Corrective Exercise Therapy for Scoliosis N/A
Recruiting NCT05128279 - Adolescent and Young Adulte Scoliosis
Withdrawn NCT04633031 - The Effect of Bracing on Sagittal Balance in Scoliosis
Recruiting NCT03978273 - Effects of Real-Time Feedback Assisted Self-Correction on the Posture of Scoliotic Patients N/A
Recruiting NCT06161038 - Precision Medicine for Nociception, Sngception and Proprioception. N/A
Not yet recruiting NCT06055140 - Evaluation of Thoracolumbar Fascia and Relationship With Low Back Pain in Individuals With Idiopathic Scoliosis
Active, not recruiting NCT05001568 - Validation of a New Optimized Nighttime Providence Brace for Personalized Treatment of Adolescent Idiopathic Scoliosis N/A
Terminated NCT03663088 - Effect of Global Postural Re-education in Idiopathic Scoliosis N/A
Recruiting NCT05575596 - Influence of Social Deprivation and Remoteness on Quality of Life in Adolescent's Surgical Scoliosis
Completed NCT04714632 - Function of Inner Ear Such as Balance and Perception of Verticality in Children With Idiopathic Scoliosis
Not yet recruiting NCT05347056 - The Effect of Vertebral Body Tethering on Lumbar Paraspinal Muscle Cross-Section Area in Adolescent Idiopathic Scoliosis
Completed NCT05333796 - The Effect of Back Muscles Activation on Idiopathic Scoliosis Using Surface Electromyography N/A
Completed NCT03190668 - Skeletal Muscle and Adipose Tissue Study Phase 4
Completed NCT03209752 - Prediction of 3D Effect of Brace in Idiopathic Scoliosis Treatment Using EOS Imaging System and "Anatomic Transfer".
Active, not recruiting NCT02651324 - Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Phase 4
Completed NCT01019109 - Scoliosis Surgery Using the PASS® LP System
Not yet recruiting NCT06407843 - Effects of Schroth Method in Idiopathic Scoliosis N/A
Not yet recruiting NCT06298812 - REFLECT Scoliosis System Post Approval Study N/A
Recruiting NCT06331143 - Analgesic Efficacy of Mid-Transverse Process to Pleura (MTP) Block and Intrathecal Morphine in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion N/A