Anesthesia and Motor Evoked Potential (MEP) Recruitment

Idiopathic Scoliosis Clinical Trial

Official title:

The Effect of Anesthesia on the Recruitment of Motor Evoked Potentials Using an Increased Number of Pulses

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02199314
• Other study ID #: 2012-1065
• Status: Completed
• Phase: N/A
• Start date: March 2013
• Est. completion date: March 2017

Study information

• Verified date: November 2017
• Source: Children's Hospital Medical Center, Cincinnati
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Test the hypothesis to recruit larger motor responses to transcranial stimulation.

Description:

The study is designed to test the hypothesis that it is possible to recruit larger motor responses to transcranial stimulation by increasing the number of stimulating pulses under both baseline conditions and conditions of increased anesthetic suppression of the motor responses.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: March 2017
• Est. primary completion date: April 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Years to 17 Years

Eligibility

Inclusion Criteria:

• Age 12 through 17 years

• Diagnosis of idiopathic scoliosis

• Scheduled for posterior spinal fusion with neurophysiological monitoring

• No known allergies to propofol or remifentanil

• No contraindication to total intravenous anesthesia

• No contraindications to the administration of volatile agents

Exclusion Criteria:

• Failure to consent or assent to study

• Diagnosis other than idiopathic scoliosis

• Poorly controlled seizures or the presence of a cochlear implant

• Patient history or family history of malignant hypothermia or mitochondrial myopathies

Related Conditions & MeSH terms

• Idiopathic Scoliosis
• Scoliosis

Intervention

Drug:
• Desflurane

Locations

Country	Name	City	State
United States	Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio

Sponsors (1)

Lead Sponsor	Collaborator
Children's Hospital Medical Center, Cincinnati

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of Pulse Train Length on Transcranial Motor Evoked Potentials (TcMEP) Area Under Total Intravenous Anesthesia (TIVA) and TIVA Plus 3% Desflurane	A series of 15 transcranial motor evoked potentials are recorded under a TIVA anesthetic and again after addition of 3% desflurane for 5 minutes at two different time points in a surgical procedure. The series consisted of 3 runs of 5,6, 7, 8, and 9 pulse trains, each train separated by 30 seconds. The 3 runs were averaged to give and average value of TcMEP amplitude and area for the 5,6,7,8 and 9 pulse trains. The data were used to compute regression coefficients for area vs pulse length for the TIVA case and TIVA plus desflurane for each participant who completed the study..The final measure is the number of participants who had a MEP area ratios significantly different from 1 at all times and conditions; that is for TIVA alone and TIVA plus desflurane, at both time points.	15 minutes