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Gluten Free Diet in IBS Patients Stratified According to Their Antigliadin Status — GFD_IBS  

IBS - Irritable Bowel Syndrome Clinical Trial

Official title:
The Role of Antigliadin Antibodies in Predicting the Beneficial Effect of Gluten Free Diet in Unselected IBS Patients

Clinical Trial Summary

Gluten-free diet has been shown to improve gut symptoms in patients with celiac disease and also in adult patients with diagnosis of Irritable Bowel Syndrome (Rome III criteria).

Antibodies to native gliadin (AGA) have been suggested as a potential diagnostic marker of response to GFD. However, this has not been tested in a prospective study in IBS patients. Identification of predictors of a symptomatic response to GFD within the IBS population would improve the clinical management of these patients.

The purpose of this study is to evaluate the effect of gluten-free diet on gastrointestinal symptoms and gut motility in patients with Irritable Bowel Syndrome stratified according to their antigliadin antibodies status.

Additional purposes include investigating effects gluten free diet may have on other parameters:

- Improvement of mood

- Quality of life and general well-being

- Changes in gut microbiota

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03492333
Study type Interventional
Source McMaster University
Contact
Status Completed
Phase N/A
Start date April 30, 2012
Completion date May 30, 2016
View Details
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