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Intestinal Epithelial Fucosylation Affects the Efficacy of Ustekinumab in Crohn's Disease

IBD Clinical Trial

Official title:
Intestinal Epithelial Fucosylation Affects the Efficacy of Ustekinumab in Crohn's Disease

Clinical Trial Summary

The loss of response rate of ustekinumab(UST) is high, and the specific mechanism has not yet been elucidated. Molecular markers that can accurately predict the efficacy of UST are urgently needed to provide theoretical basis for guiding individualized treatment. Therefore, this study intends to explore the impact of intestinal epithelial fucosylation levels on the efficacy of UST in patients with Crohn's disease(CD), aiming to provide predictable molecular markers for UST to accurately treat CD.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06203158
Study type Observational
Source Second Affiliated Hospital of Wenzhou Medical University
Contact
Status Completed
Phase
Start date December 26, 2023
Completion date February 28, 2024
View Details
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