Airway Involvement In Inflammatory Bowel Disease

IBD Clinical Trial

Official title:

Spectrum Of Airway Involvement In Inflammatory Bowel Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06090045
• Other study ID #: IBD&Airway
• Status: Not yet recruiting
• Start date: November 20, 2023
• Est. completion date: December 25, 2024

Study information

• Verified date: October 2023
• Source: Assiut University
• Contact: Hend Saleh, MD
• Phone: 01098987812
• Email: hend.m.saleh[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To estimate prevalence of subclinical airway injuries among IBD patients. To investigate relationship between activity of IBD and airways

Description:

Airway diseases are the most commonly described lung manifestations of inflammatory bowel disease (IBD). However, the similarities in disease pathogenesis and the sharing of important environmental risk factors and genetic susceptibility suggest that there is a complex interplay between IBD and airway diseases.Extraintestinal manifestations (EIM) commonly occur in inflammatory bowel diseases (IBD), with a prevalence rate between 21%-41% reported in various series. Crohn's disease (CD) presents with EIM more frequently than ulcerative colitis (UC). Pulmonary involvement complicating IBD was originally considered rare (with a frequency rate < 1%), but the first case series published in 1976 assisted in better recognition, evaluation and description of IBD related respiratory disease. Pulmonary involvement is often asymptomatic and may be detected solely on the basis of abnormal screening tests. This review will focus on the involvement of the airways in the context of IBD. Although IBD related PM were originally considered rare, certain population-based studies have revealed significant interrelationships between the lungs and IBD. Bernstein and colleagues in a large population-based study in North America in 2005 reported that airway disorders in general (including asthma and bronchitis) were the most common extraintestinal manifestation in subjects with CD and the second most common in subjects with UC, with the prevalence of asthma in this population between 7%-8%. In another retrospective study from the opposite view, Birring reported that IBD was 4 times more prevalent among patients with airway diseases, particularly non-asthmatic patients with productive cough, than in the general population.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 70
• Est. completion date: December 25, 2024
• Est. primary completion date: November 20, 2024
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients attended to IBD clinic at Tropical Department

Exclusion Criteria:

1. Age: less than 18 years

2. Unstable patients or need for ICU admission

Related Conditions & MeSH terms

• IBD
• Inflammatory Bowel Diseases

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (2)

Byrd KM, Gulati AS. The "Gum-Gut" Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances. Front Immunol. 2021 Feb 19;12:620124. doi: 10.3389/fimmu.2021.620124. eCollection 2021. — View Citation

Vutcovici M, Brassard P, Bitton A. Inflammatory bowel disease and airway diseases. World J Gastroenterol. 2016 Sep 14;22(34):7735-41. doi: 10.3748/wjg.v22.i34.7735. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Predictors of airway diseases in patients with IBD	FROM risk factors	baseline
Secondary	-Prevalence of of subclinical airway injuries among IBD patients presented to Tropical Department in Assiut University Hospital	from statistical anyalasis	baseline