Clinical Trials Logo
  1. Home
  2. Hypoxia
  3. NCT01260428
  4. Details
NCT01260428 Clinical Trial

Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia

Hypoxia Clinical Trial

— hypex  

Official title:
Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01260428
Other study ID # 10-AGIR-2
Secondary ID
Status Recruiting
Phase N/A
First received December 14, 2010
Last updated February 27, 2012
Start date February 2011

Study information
Verified date February 2012
Source AGIR à Dom
Contact Bernard Wuyam, MD, PhD
Phone 33 (0)4 76 76 93 03
Email BWuyam@chu-grenoble.fr
Is FDA regulated No
Health authority AFSAPS : France
Study type Observational

Clinical Trial Summary

Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.

Description:

Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.

Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).

FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria :

- active (> 2 hrs/week physical activity)

- adult

- non smoking volunteers

Exclusion Criteria :

- cardiac, respiratory, neuromuscular, metabolic pathology

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Device:
• threshold PEEP
Various set of pressures : 0, 5, 10 cm H20; pursed lips breathing

Locations
Country Name City State
France CHU de Grenoble La Tronche Isere

Sponsors (1)
Lead Sponsor Collaborator
AGIR à Dom

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary SpO2 after three minutes of PEEP vs spontaneous breathing mean over 1 minute No
Secondary peripheral HbO2/DeoxyHb after three minutes of PEEP / PLB vs. spontaneous breathing 1 min No
Secondary cardiac output after three min of PEEP vs. spontaneous breathing mean over 1 min No
Secondary pattern of breathing (fR, VT, PETCO2) after three min of PEEP vs. spontaneous breathing 1 min No
See also
  Status Clinical Trial Phase
Recruiting NCT04498598 - Structural Modification In Supraglottic Airway Device N/A
Completed NCT05532670 - N600X Low Saturation Accuracy Validation
Enrolling by invitation NCT04106401 - Intravascular Volumes in Hypoxia During Antarctic Confinement N/A
Recruiting NCT05883137 - High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Not yet recruiting NCT05817448 - Hypoxia-induced Autophagy in the Pathogenesis of MAP
Recruiting NCT02661152 - DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC. Phase 3
Terminated NCT02801162 - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard N/A
Completed NCT02943863 - Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia N/A
Not yet recruiting NCT02201875 - Intrinsic Periodic Pattern of Breathing N/A
Completed NCT02105298 - Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study) N/A
Completed NCT01922401 - Inverse Ratio Ventilation on Bariatric Operation N/A
Active, not recruiting NCT01681238 - Goal-directed Therapy in High-risk Surgery N/A
Completed NCT01463527 - Using Capnography to Reduce Hypoxia During Pediatric Sedation N/A
Completed NCT01507623 - Value of Capnography During Nurse Administered Propofol Sedation (NAPS) N/A
Withdrawn NCT00638040 - The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression N/A
Active, not recruiting NCT06097754 - Intermittent Exogenous Ketosis (IEK) at High Altitude N/A
Completed NCT04589923 - The VISION-Acute Study
Completed NCT05044585 - Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers N/A
Completed NCT03659513 - The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
Completed NCT03221387 - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients N/A