Hypoxia Clinical Trial
Official title:
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
This study will investigate the effects of ketone ester drinks on cognitive performance in hypoxia.
In the setting of altitude-induced hypoxia, cognitive capacity degrades and can compromise
both individual and team performance. This degradation is linked to falling brain energy
(ATP) levels and an increased reliance on anaerobic energy production from glucose. Ketone
bodies are the evolutionary alternative substrate to glucose for brain metabolic
requirements; previous studies have shown that the presence of elevated ketone bodies
(ketosis) maintains brain ATP levels and reduce cerebral anaerobic glycolysis during hypoxia.
Ketosis can be achieved when fasting or following a ketogenic diet; however, these approaches
are impractical. Exogenous ketone ester supplementation allows for rapid (< 30 mins) and
significant elevation of blood ketone levels without the need to maintain a diet or fast.
HVMN, in collaboration with researchers at IHMC, proposes a study to investigate the effects
of consuming an FDA-approved ketone ester 'food' on cognitive performance in the setting of
hypoxia. For the proposed 4-arm within-subject study, participants will complete a cognitive
performance test battery under the conditions of normoxia and then hypoxia following
consumption of a ketone ester drink or a placebo drink (N.B for each study drink cognitive
performance in both hypoxia and normoxia will be assessed in ONE visit):
VISIT A:
Arm1: Normoxia + Placebo Arm 2: Hypoxia + Placebo
VISIT B:
Arm 3: Normoxia + Ketone ester Arm 4: Hypoxia + Ketone ester
The investigators hypothesize that ketone ester supplementation will attenuate
hypoxia-induced deterioration of operator cognitive performance.
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