Clinical Trials Logo
  1. Home
  2. Hypoxemic Respiratory Failure
  3. NCT04971148

Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia

Hypoxemic Respiratory Failure Clinical Trial

Official title:
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia, and Patients' Responses to Different Flows Above Their Peak Tidal Inspiratory Flow During High Flow Nasal Cannula Therapy

Clinical Trial Summary

In this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (PTIF) pre and post extubation to explore the correlation between the two PTIFs. Moreover, different HFNC flows would be applied, to explore the patient response in terms of oxygenation and lung aeration to different flow ratios that matched and are above post-extubation PTIF.

Clinical Trial Description

High-flow nasal cannula (HFNC) oxygen therapy has been shown to improve oxygenation, reduce the need for intubation for patients with acute hypoxemic respiratory failure (AHRF) and avoid reintubation for post-extubation patients who had high-risk factors. HFNC refers to the delivery of gas at flows that exceed the patient peak inspiratory flow during tidal breathing, However, patient peak tidal inspiratory flow (PTIF) is found to vary greatly among different patients, from 20 to 50 L/min, making it difficult to properly set HFNC in a way to achieve the desired effects. In two recently published studies in intubated patients, PTIF varied from 25-65 L/min or 40-80 L/min, thus this study aims to investigate the correlation between pre-extubation PTIF in different modalities of SBT and post-extubation PTIF for adult patients, who are indicated to use HFNC immediately after extubation. In addition, the investigators aim to explore the patient response in terms of oxygenation and lung aeration to different flow ratios that matched and are above post-extubation PTIF. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04971148
Study type Interventional
Source Rush University Medical Center
Contact
Status Terminated
Phase N/A
Start date April 7, 2022
Completion date August 8, 2023
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT06033560 - The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2)-Related Hypoxemic Respiratory Failure
Completed NCT04357457 - Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia Phase 3
Completed NCT04982341 - HFNC and Prone Positioning in Awake Patients With Severe COVID-19
Recruiting NCT05880836 - In Line Aerosol Nebulization With High Flow N/A
Completed NCT04934163 - Flow Rates of High-flow Nasal Cannula and Extubation Outcome N/A
Completed NCT03282552 - High Flow Oxygen Therapy Versus Conventional Oxygen Therapy in Cardiac Surgery Patients N/A
Recruiting NCT04079465 - Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia N/A
Recruiting NCT05363332 - Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients
Active, not recruiting NCT05155202 - Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit
Withdrawn NCT04381923 - COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia N/A
Recruiting NCT04402879 - CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals N/A
Not yet recruiting NCT06064409 - Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
Completed NCT04445246 - Inhaled Iloprost for Suspected COVID-19 Respiratory Failure Phase 2
Completed NCT03438383 - Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery N/A
Completed NCT04694638 - Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection N/A
Completed NCT04853979 - Awake Prone Positioning in COVID-19 Suspects With Hypoxemic Respiratory Failure N/A
Recruiting NCT05089695 - Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure N/A
Completed NCT05124197 - Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study
Completed NCT03589482 - Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure N/A
Completed NCT03174002 - Handling Oxygenation Targets in the Intensive Care Unit Phase 4