Hypoxemia Clinical Trial
Official title:
Conduct of High Flow Nasal Cannula Oxygen During Acute Hypoxemic Respiratory Failure: a Multicentre Observational Study
Although many studies have investigated the clinical benefits of nasal high flow during acute hypoxemic respiratory failure, there is no data (and even less so recommendations) on how to best conduct this technique, including its initiation and its weaning periods. Investigators will assess in a multicenter, observational study, the way clinicians use nasal high flow therapy in patients with acute respiratory failure in order to try identify one or more strategies that may be then compared in an interventional study.
Nasal high flow oxygen therapy is increasingly used as a first-line treatment for hypoxemic
acute respiratory failure, because of its remarkable tolerance (in comparison with NIV) and
its physiological effects (nasopharyngeal dead space washout, positive end-expiratory
pressure effect with possible alveolar recruitment, better matching with the patient's
inspiratory flow, more reliable and adjustable FiO2); that together contribute to a reduction
in respiratory workload and better oxygenation.
Although many studies have investigated the clinical benefits of nasal high flow during acute
hypoxemic respiratory failure, there are no data (and even less recommendations) on how to
best conduct this technique, including its initiation and its weaning periods.
Because different approaches exist among clinicians, investigators believe that a multicenter
observational study that would collect data regarding the different ways high flow is
conducted in patients with acute respiratory failure is necessary before performing an
interventional study that would test and compare different strategies in order to answer the
question: what are the best strategies (in terms of flow and FiO2 settings) to initiate and
to wean high-flow oxygen therapy in patients with acute respiratory failure?
Investigators will assess in a multicenter, observational study, the way clinicians use nasal
high flow therapy in patients with acute respiratory failure in order to try identify one or
more strategies that may be then compared in an interventional study.
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