Clinical Trials Logo
  1. Home
  2. Hypovitaminosis D
  3. NCT02351284

Impact of Hypovitaminosis D on Bone Disease in HIV Infected Patients — PuraVIHta  

Hypovitaminosis D Clinical Trial

Official title:
Impact of Hypovitaminosis D in Metabolic Disturbances and Bone Metabolism, and Changes in Patients Receiving Vitamin D Supplementation

Clinical Trial Summary

To determine the prevalence of hypovitaminosis D in HIV infected patients, and the consequences on secondary hyperparathyroidism, and bone mineral density (BMD). Also, to establish the improvement in vitamin D status, parathyroid hormone (PTH) and BMD, in case of receiving vitamin D supplementation, during a follow up period of at least 1 year.

Clinical Trial Description

This study deals with the impact of vitamin D on metabolism and bone health in HIV infected patients. To answer the questions about the importance of this hormone in this population, we designed a cohort study about the prevalence of vitamin D deficiency (measured as 25-hydroxy-vitamin D), classifying it in severe deficiency (<10 ng/ml), deficiency (< 20 ng/ml), or insufficiency (< 30 ng/ml), the relationship with secondary hyperparathyroidism (PTH > 65 pg/ml), and related BMD by dual X-ray absorptiometry (DXA). These results will be adjusted by baseline factors, such as age, gender, body mass index (BMI), hepatitis C virus (HCV) coinfection, risk practice for HIV infection, CD4+ count, antiretroviral therapy, and HIV RNA level. In patients receiving vitamin D supplementation according to clinical decision, it will be evaluated the changes in percentage of hypovitaminosis D and/or secondary hyperparathyroidism, and the effect on BMD. Bone biomarkers will be collected to determine the impact of changes secondary to vitamin D improvement in the bone evolution. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02351284
Study type Observational [Patient Registry]
Source Asociacion para el Estudio de las Enfermedades Infecciosas
Contact Jose L Casado, MD
Phone 34913368672
Email jcasado.hrc@salud.madrid.org
Status Recruiting
Phase
Start date January 12, 2019
Completion date December 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT05376865 - Effects of Vitamin D Supplementation on Obesity, Inflammatory and Metabolic Markers N/A
Not yet recruiting NCT05214040 - Vitamin D Insufficiency inVestigation Among hospitaLizeD Inpatients
Completed NCT02802449 - To Study the Nutri-Genomic Response of Vit-D Supplementation in African-Americans N/A
Recruiting NCT00992797 - Diabetes Intervention Trial With Vitamin D in Subjects of Nordic and Sub-Indian Ethnicity Phase 2
Completed NCT00960232 - Vitamin D, Blood Pressure, Lipids, Infection and Depression Phase 3
Completed NCT02543671 - Investigation of Vitamin D3 Enriched, Reduced-fat Yellow Cheese Efficacy to Prevent Vitamin D Deficiency N/A
Completed NCT01793402 - Vitamin D Status and the Adequacy of Vitamin D Intake in Early Preterm Infants N/A
Completed NCT01240213 - Vitamin D, Diet and Activity Study N/A
Completed NCT00887666 - Pilot Study: Hypovitaminosis D, Hyperparathyroidism and Hypomagnesemia in Patients With Congestive Heart Failure N/A
Completed NCT05425914 - Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Serum Vitamin D Level Phase 3
Not yet recruiting NCT04829487 - The Role of Vitamin D Supplementation on Pain in Women With Primary Dysmenorrhea and Hypovitaminosis D N/A
Completed NCT05372224 - Effect of Vitamin D and Denosumab on Bone Remodelling in Women With Postmenopausal Osteoporosis N/A
Completed NCT02101151 - Effect of Vitamin D Supplementation on the Metabolic Control and Body Composition of Type 2 Diabetes Subjects in Ajman (UAE) N/A
Completed NCT00695474 - Vitamin D and Type 2 Diabetes - a Cross Sectional Study N/A
Completed NCT02434380 - Effect of Vitamin D Replacement on Maternal and Neonatal Outcomes Phase 3
Completed NCT02534714 - Analysis of Hypovitaminosis D and Osteopenia/Osteoporosis in Spinal Disease Patients Who Underwent a Spinal Fusion at Illinois Neurological Institute, Peoria, IL., a Retrospective Review From November 1, 2012 to October 31, 2014 and Prospective Pilot From July 1, 2015-June 30, 2016
Withdrawn NCT00944606 - Vitamin D Versus Placebo in the Treatment of Vague Musculoskeletal Pain in Children N/A
Recruiting NCT06138249 - Cholecalciferol and Calcifediol Are Both Useful to Improve Vitamin D Serum Levels N/A
Completed NCT05346419 - Antiresorptive Effect of Treatment With Risedronate and Vitamin D in Postmenopausal Patients N/A
Completed NCT03381378 - Vitamin D and Hand Grip Strength at 5 Years in Odense Child Cohort N/A