Identification of Non-responders to Levothyroxine Therapy

Status Completed

Clinical Trial Summary

The purpose of this study is to assess differential effects of T4 and T3 on cell and tissue level

Clinical Trial Description

15-20% of the patients with hypothyroidism remain symptomatic, despite adequate thyroxine substitution. Endocrinologists are split in their opinion on combination therapy with T4 and T3 on patients with poorly regulated hypothyroidism. There are no objective means, by which to identify individuals who would benefit from combination therapy. The purpose of this study is to assess differential effects of T4 and T3 on body temperature, metabolism, muscle strength and brain function. The main aim is to try to identify biomarkers reflecting different effects of T4 and T3 on cell and tissue level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03627611
Study type	Interventional
Source	Oslo University Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	August 14, 2018
Completion date	June 22, 2020

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