Hypothyroidism Clinical Trial
Official title:
Effects of Thyroid Hormone Withdrawal on Metabolic and Cardiovascular Parameters During Radioactive Iodine Therapy in Differentiated Thyroid Cancer
1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant
number of them experience severe hypothyroidism in preparation for radioactive iodine
(RAI) therapy after total thyroidectomy.
2. Because the function of thyroid hormone is closely linked with lipid and glucose
metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy
may induce the changes of metabolic parameters.
3. We investigate the effects of thyroid hormone withdrawal on metabolic and
cardiovascular parameters during radioactive iodine therapy in differentiated thyroid
cancer.
1. Study design measurement of various parameters during hypothyroid state (before 1
month, the day and after 1 month of RAI therapy)
2. Measurements
1. Measurement of metabolic and cardiovascular parameters
- glucose profiles : HbA1c, fasting glucose level
- lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol,
triglyceride
- adipocytokines : retinol binding protein(RBP)
- 4, leptin, resistin, adiponectin
- markers of endothelial and cardiac function : high-sensitivity C-reactive
protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
- bone turnover markers : CTX, bone ALP
2. Scoring of symptoms and signs of hypothyroidism (Zulewski score)
- symptoms
- physical signs
;
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05975866 -
The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With Hashimato
|
N/A | |
| Not yet recruiting |
NCT05334771 -
Early Detection of Endolymphatic Hydrops in Hypothyroid Patients
|
||
| Withdrawn |
NCT01707056 -
The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma
|
N/A | |
| Completed |
NCT00094237 -
Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke
|
N/A | |
| Recruiting |
NCT06015620 -
Comorbidities Resolution After MGB Surgery and Change in Body Composition
|
||
| Completed |
NCT03612908 -
TSHβX1 and D2 THR92ALA in Pregnancy
|
||
| Completed |
NCT04782856 -
Energy Metabolism in Thyroidectomized Patients
|
Phase 2 | |
| Completed |
NCT01921452 -
Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit
|
Phase 4 | |
| Completed |
NCT01197183 -
Observational Study With Prospective and/or Retrospective Follow-up, Without Modifying Patient Treatment and Follow-up Practices for the Initial Treatment of Hypothyroidism in France
|
N/A | |
| Recruiting |
NCT05247476 -
Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients.
|
Phase 4 | |
| Recruiting |
NCT03754621 -
Upper Limit for TSH of First and Second Trimester Pregnancy in Turkey
|
||
| Completed |
NCT02959827 -
Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States
|
||
| Completed |
NCT04124705 -
A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants
|
Phase 2 | |
| Withdrawn |
NCT02577367 -
Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding
|
Phase 4 | |
| Completed |
NCT04098991 -
Improving White Matter Integrity With Thyroid Hormone
|
||
| Not yet recruiting |
NCT03257566 -
Hypothyroidism in Patients With Type 1 Diabetes
|
N/A | |
| Terminated |
NCT02567877 -
Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?
|
||
| Completed |
NCT02280330 -
Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months
|
Phase 4 | |
| Completed |
NCT00403390 -
Generic vs. Name-Brand Levothyroxine
|
N/A | |
| Not yet recruiting |
NCT06096454 -
Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance
|
Phase 4 |